A Study to Investigate Tislelizumab Administered as Subcutaneous Injection Versus Intravenous Infusion Plus Chemotherapy in Patients With Unresectable or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma

PHASE3RecruitingINTERVENTIONAL
Enrollment

351

Participants

Timeline

Start Date

August 27, 2025

Primary Completion Date

October 30, 2027

Study Completion Date

April 22, 2028

Conditions
Metastatic Gastric AdenocarcinomaGastroesophageal Junction Adenocarcinoma
Interventions
DRUG

Subcutaneous Tislelizumab

Administered by subcutaneous injection

DRUG

Intravenous Tislelizumab

Administered by intravenous infusion

DRUG

Cisplatin

Administered by intravenous infusion

DRUG

Leucovorin

Administered by intravenous infusion

DRUG

5-fluorouracil (5-FU)

Administered by intravenous infusion

DRUG

Oxaliplatin

Administered by intravenous infusion

DRUG

Capecitabine

Administered orally

Trial Locations (95)

1090

NOT_YET_RECRUITING

Medical Univeristy Vienna, Vienna

1425

NOT_YET_RECRUITING

Hospital Aleman, CABA

4010

NOT_YET_RECRUITING

Krankenhaus Der Barmherzigen Schwestern Linz, Linz

8036

NOT_YET_RECRUITING

Hospital Clinic de Barcelona, Barcelona

10000

NOT_YET_RECRUITING

Vseobecna Fakultni Nemocnice V Praze, Prague

13620

NOT_YET_RECRUITING

Seoul National University Bundang Hospital, BundangGu SeongnamSi

16132

NOT_YET_RECRUITING

Ospedale Policlinico San Martino Irccs Per L Oncologia, Divisione Ematologia Centro Trapianti Di Mid, Genova

20089

NOT_YET_RECRUITING

Istituto Clinico Humanitas, Rozzano

20133

NOT_YET_RECRUITING

Fondazione Irccs Istituto Nazionale Dei Tumori, Milan

29200

NOT_YET_RECRUITING

Chru de Brest Hopital Cavale Blanche, Brest

31008

NOT_YET_RECRUITING

Hospital Universitario de Navarra, Pamplona

34295

NOT_YET_RECRUITING

Medical Park Florya Hospital, Sefaköy

37232

NOT_YET_RECRUITING

Vanderbilt University, Nashville

41404

NOT_YET_RECRUITING

Kyungpook National University Chilgok Hospital, BukGu

46010

NOT_YET_RECRUITING

Hospital Clinico Universitario de Valencia, Valencia

50009

NOT_YET_RECRUITING

Hospital Universitario Miguel Servet, Zaragoza

56126

NOT_YET_RECRUITING

Aou Pisana, Stabilimento Di Santa Chiara, Pisa

59000

NOT_YET_RECRUITING

Hopital Claude Huriez Chu Lille, Lille

60611

NOT_YET_RECRUITING

Northwestern University, Chicago

63044

NOT_YET_RECRUITING

St Louis Cancer Care, Llp, Bridgeton

68020

NOT_YET_RECRUITING

Centro de Investigacion Clinica de Oaxaca, Oaxaca City

77900

NOT_YET_RECRUITING

Fakultni Nemocnice Olomouc, Olomouc

84000

NOT_YET_RECRUITING

Institut Sainte Catherine, Avignon

97070

NOT_YET_RECRUITING

Medical Care and Research Sa de Cv, Mérida

97301

RECRUITING

Oregon Oncology Specialists, Salem

98405

NOT_YET_RECRUITING

Northwest Medical Specialties, Tacoma

100021

NOT_YET_RECRUITING

Cancer Hospital Chinese Academy of Medical Sciences, Beijing

110001

NOT_YET_RECRUITING

The First Hospital of China Medical University, Shenyang

210008

NOT_YET_RECRUITING

Nanjing Drum Tower Hospital,the Affiliated Hospital of Nanjing University Medical School, Nanjing

230601

NOT_YET_RECRUITING

The Second Hospital of Anhui Medical University, Hefei

250117

NOT_YET_RECRUITING

Shandong Cancer Hospital, Jinan

272000

NOT_YET_RECRUITING

Affiliated Hospital of Jining Medical University, Jining

300060

NOT_YET_RECRUITING

Tianjin Medical University Cancer Institute and Hospital, Tianjin

325000

NOT_YET_RECRUITING

The First Affiliated Hospital of Wenzhou Medical University, Wenzhou

341000

NOT_YET_RECRUITING

Ganzhou Peoples Hospital Ganzhou Hospital Affiliated to Nanchang University, Ganzhou

361003

NOT_YET_RECRUITING

The First Affiliated Hospital of Xiamen University, Xiamen

450000

NOT_YET_RECRUITING

Henan Cancer Hospital, Zhengzhou

450052

RECRUITING

The First Affiliated Hospital of Zhengzhou University, Zhengzhou

455001

NOT_YET_RECRUITING

Anyang Tumor Hospital, Anyang

85224-5665

NOT_YET_RECRUITING

Ironwood Cancer and Research Centers, Chandler

90720-3302

NOT_YET_RECRUITING

Cancer and Blood Specialty Clinic, Los Alamitos

80909-4501

NOT_YET_RECRUITING

University of Colorado Health Memorial Hospital, Colorado Springs

33013-3804

NOT_YET_RECRUITING

Bioresearch Partners Holding Hialeah Hospital, Hialeah

32806-2134

NOT_YET_RECRUITING

Orlando Health Ufhealth Cancer Center, Orlando

60521-0509

RECRUITING

Hope and Healing Cancer Services, Hinsdale

66160-8500

NOT_YET_RECRUITING

University of Kansas Medical Center Research Institute, Kansas City

04092

NOT_YET_RECRUITING

New England Cancer Specialists, Westbrook

68506-7548

NOT_YET_RECRUITING

Nebraska Hematology Oncology, Lincoln

89169-3321

NOT_YET_RECRUITING

Comprehensive Cancer Centers of Nevada, Las Vegas

08822-4603

NOT_YET_RECRUITING

Hunterdon Hematology Oncology, Flemington

07932-1049

NOT_YET_RECRUITING

Summit Medical Group, Florham Park

77030-3907

NOT_YET_RECRUITING

Md Anderson Cancer Center, Houston

76508-0001

NOT_YET_RECRUITING

Scott and White Memorial Hospital, Temple

F5300COE

NOT_YET_RECRUITING

Fundacion Cori Para La Investigacion Y Prevencion Del Cancer, La Rioja

14784-400

NOT_YET_RECRUITING

Hospital de Amor Barretos, Barretos

89035-510

NOT_YET_RECRUITING

CECAP, Blumenau

71681-603

NOT_YET_RECRUITING

Hospital Brasilia, Brasília

59012-300

NOT_YET_RECRUITING

Hospital Universiario Onofre Lopes, Natal

90610-000

NOT_YET_RECRUITING

Hospital Sao Lucas Da Pucrs, Porto Alegre

50070-902

NOT_YET_RECRUITING

IMIP, Recife

20231-050

NOT_YET_RECRUITING

Inca Instituto Nacional de Cancer, Rio de Janeiro

15090-000

NOT_YET_RECRUITING

Fundacao Faculdade Regional de Medicina de Sao Jose Do Rio Preto, São José do Rio Preto

01246-000

NOT_YET_RECRUITING

Icesp Instituto Do Cancer Do Estado de Sao Paulo Octavio Frias de Oliveira, São Paulo

04501-000

NOT_YET_RECRUITING

Instituto Dor de Pesquisa E Ensino Sao Paulo, São Paulo

29043-260

NOT_YET_RECRUITING

Hospital Santa Rita de Cassia Afecc, Vitória

046099

NOT_YET_RECRUITING

Changzhi Peoples Hospital, Changzhi

030013

NOT_YET_RECRUITING

Shanxi Provincial Cancer Hospital, Taiyuan

602 00

NOT_YET_RECRUITING

Masarykuv Onkologicky Ustav, Brno

500 03

NOT_YET_RECRUITING

Fakultni Nemocnice Hradec Kralove, Hradec Králové

790 8524

NOT_YET_RECRUITING

Matsuyama Red Cross Hospital, Matsuyama

806-0034

RECRUITING

Japan Community Health Care Organization Kyushu Hospital, Kitakyushu

003-0804

RECRUITING

Nho Hokkaido Cancer Center, Sapporo

591-8025

NOT_YET_RECRUITING

Osaka Rosai Hospital, SakaiShi

569-8686

NOT_YET_RECRUITING

Osaka Medical and Pharmaceutical University Hospital, Takatsukishi

362-0806

RECRUITING

Saitama Cancer Center, Kitaadachigun

431-3192

NOT_YET_RECRUITING

Hamamatsu University School of Medicine, University Hospital, Hamamatsushi

320-0834

NOT_YET_RECRUITING

Tochigi Cancer Center, Utsunomiya

130-8575

RECRUITING

Tokyo Metropolitan Bokutoh Hospital, SumidaKu

113-8519

NOT_YET_RECRUITING

Institute of Science Tokyo Hospital, Tokyo

03100

NOT_YET_RECRUITING

Health Pharma Professional Research Sa de Cv, Mexico City

30-727

NOT_YET_RECRUITING

Pratia McM Krakow, Krakow

45-061

NOT_YET_RECRUITING

Opolskie Centrum Onkologii, Opole

02-781

NOT_YET_RECRUITING

Narodowy Instytut Onkologii Im Marii Sklodowskiej Curie Hematology Unit, Warsaw

00935

RECRUITING

Pan American Oncology Trials, Llc, Rio Piedras

06351

NOT_YET_RECRUITING

Samsung Medical Center, GangnamGu

03722

NOT_YET_RECRUITING

Severance Hospital Yonsei University Health System, SeodaemunGu

03080

NOT_YET_RECRUITING

Seoul National University Hospital, Seoul

05505

NOT_YET_RECRUITING

Asan Medical Center, SongpaGu

01060

NOT_YET_RECRUITING

Medical Park Seyhan Hospital, Adana

NOT_YET_RECRUITING

Acibadem Adana Hospital, Kuruköprü

06200

NOT_YET_RECRUITING

Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, Ankara

BT9 7AB

NOT_YET_RECRUITING

Belfast City Hospital, Belfast

CB2 0QQ

NOT_YET_RECRUITING

Cambridge University Hospitals Nhs Foundation Trust, Cambridge

DD1 9SY

NOT_YET_RECRUITING

Ninewells Hospital and Medical School, Dundee

CH63 4JY

NOT_YET_RECRUITING

Clatterbridge Cancer Centre, Metropolitan Borough of Wirral

Sponsors

Lead Sponsor

All Listed Sponsors
lead

BeiGene

INDUSTRY