Comparison of Initial Treatment for Carpal Tunnel Syndrome Related to Rheumatic Diseases: Corticosteroid Injection Versus Nighttime Splinting

NANot yet recruitingINTERVENTIONAL
Enrollment

248

Participants

Timeline

Start Date

August 1, 2025

Primary Completion Date

August 1, 2027

Study Completion Date

August 1, 2027

Conditions
Carpal Tunnel Syndrome (CTS)Rheumatic Diseases
Interventions
DEVICE

Nighttime Splinting

Nighttime splinting for 6 weeks.

DRUG

Corticosteroid Injection

Local corticosteroid injection (triamcinolone acetonide 40mg). A single injection of triamcinolone acetonide 40mg mixed with an equal volume of 1% lidocaine is administered. The injection is performed under ultrasound guidance and anatomical landmarks to target the proximal carpal tunnel. With the wrist extended, the needle is typically inserted on the ulnar side of the palmaris longus tendon, approximately 1 cm proximal to the wrist crease. If blood is aspirated or the patient reports paresthesia (which usually indicates nerve irritation), the injection site should be adjusted.

OTHER

Evaluation and Dynamic Adjustment

6 weeks later, all patients will undergo evaluation of their initial treatment. Further therapeutic decisions will be made based on physician assessment, including: continuing nighttime splinting, administering corticosteroid injections to patients who initially received only the splint, adding nighttime splinting for patients initially received only corticosteroid injections, and transitioning from nighttime splint use to continuous wear. Subsequently, evaluations will be conducted every 6 weeks, with dynamic adjustments to the treatment plan. Throughout the study period, physicians will perform electrophysiological examinations according to changes in patients' clinical status.

Trial Locations (3)

Unknown

Jinjiang Municipal Hospital(Shanghai Sixth People's Hospital Fujian Campus), Jinjiang

Yancheng Third People's Hospital, Yancheng

Shanghai Sixth People's Hospital, Shanghai

All Listed Sponsors
collaborator

Shanghai 6th People's Hospital

OTHER

lead

Yun Qian

OTHER