Dexmedetomidine vs Labetalol for Airway Stress in Hypertensive Craniotomy Patients

PHASE4Enrolling by invitationINTERVENTIONAL
Enrollment

60

Participants

Timeline

Start Date

April 1, 2025

Primary Completion Date

August 31, 2025

Study Completion Date

August 31, 2025

Conditions
Airway Stress Response
Interventions
DRUG

Dexmedetomidine

Participants in this arm will receive dexmedetomidine at a dose of 0.5 mcg/kg, diluted with normal saline to a total volume of 50 mL. The solution will be administered intravenously via a syringe pump at an infusion rate of 300 mL/hour, completing over 10 minutes immediately prior to extubation.

DRUG

Labetalol

Participants in this arm will receive labetalol at a dose of 0.5 mg/kg, diluted with normal saline to a total volume of 50 mL. The solution will be administered intravenously via a syringe pump at an infusion rate of 300 mL/hour, completing over 10 minutes immediately prior to extubation.

Trial Locations (1)

Unknown

Ain Shams University, Cairo

All Listed Sponsors
lead

Ain Shams University

OTHER