Effectiveness of Coenzyme Q10 and Probiotics in Periodontal Therapy During Pregnancy

NARecruitingINTERVENTIONAL
Enrollment

40

Participants

Timeline

Start Date

July 1, 2025

Primary Completion Date

January 15, 2026

Study Completion Date

January 30, 2026

Conditions
PregnancyPeriodontal DiseaseGingivitisDental PlaqueProbioticsCoenzyme Q10Microbiota
Interventions
DIETARY_SUPPLEMENT

Limosilactobacillus reuteri Prodentis®

Daily administration of Limosilactobacillus reuteri Prodentis® (1 oral tablet per day, taken after brushing in the evening), as an adjunct to non-surgical periodontal therapy and standard home care. Administered for 6 months only in the experimental arm.

OTHER

Coenzyme Q10 Toothpaste

Twice-daily use of a commercially available toothpaste containing coenzyme Q10, used as part of a home oral hygiene regimen for 6 months. All participants in both study arms will use the same toothpaste, with or without adjunctive probiotic supplementation.

Trial Locations (1)

27100

RECRUITING

Unit of Orthodontics and Pediatric Dentistry - Section of Dentistry - Department of Clinical, Surgical, Diagnostic and Pediatrics - University of Pavia, Pavia

All Listed Sponsors
lead

University of Pavia

OTHER