This Study Will Explore Whether a Combination of the Investigational Drug Mevrometostat (PF-06821497) and Enzalutamide Will Work Better Than Taking Enzalutamide Alone in Participants With mCSPC Who Are ARPI naïve.

PHASE3RecruitingINTERVENTIONAL
Enrollment

1,000

Participants

Timeline

Start Date

September 28, 2025

Primary Completion Date

September 12, 2028

Study Completion Date

December 8, 2034

Conditions
Metastatic Castration Sensitive Prostate Cancer (mCSPC)Hormone Sensitive Prostate CancerProstate CancerCancer of the Prostate
Interventions
DRUG

Mevrometostat

Oral continuous

DRUG

Placebo

Oral continuous

DRUG

Enzalutamide

Oral continuous

Trial Locations (45)

17604

NOT_YET_RECRUITING

The Centers for Advanced Urology, LLP d/b/a Keystone Urology Specialists, Lancaster

37209

NOT_YET_RECRUITING

Urology Associates, P.C., Nashville

62269

NOT_YET_RECRUITING

Cancer Care Specialists of Illinois, O'Fallon

62526

NOT_YET_RECRUITING

Cancer Care Specialists of Illinois, Decatur

72703

RECRUITING

Highlands Oncology Group, PA, Fayetteville

72758

RECRUITING

Highlands Oncology Group, PA, Rogers

72762

RECRUITING

Highlands Oncology Group, PA, Springdale

84112

NOT_YET_RECRUITING

Huntsman Cancer Institute, Salt Lake City

85741

NOT_YET_RECRUITING

Arizona Urology Specialists, PLLC, Tucson

98003

RECRUITING

Northwest Medical Specialties, PLLC, Federal Way

98332

RECRUITING

Northwest Medical Specialties, PLLC, Gig Harbor

98373

RECRUITING

Northwest Medical Specialties, PLLC, Puyallup

98391

RECRUITING

Northwest Medical Specialties, PLLC, Bonney Lake

98405

RECRUITING

Northwest Medical Specialties, PLLC, Tacoma

100050

NOT_YET_RECRUITING

Beijing Friendship Hospital Affiliate of Capital University, Beijing

200032

NOT_YET_RECRUITING

Fudan University Shanghai Cancer Center, Shanghai

210008

RECRUITING

Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School, Nanjing

215004

NOT_YET_RECRUITING

The Second Affiliated Hospital of Soochow University, Suzhou

223300

NOT_YET_RECRUITING

First Huai'an Hospital Affiliated to Nanjing Medical University, Huai'an

226361

RECRUITING

Nantong Tumor Hospital, Nantong

241001

RECRUITING

Wannan Medical College Yijishan Hospital, Wuhu

250001

NOT_YET_RECRUITING

Shandong Provincial Hospital, Jinan

250012

NOT_YET_RECRUITING

Qilu Hospital of Shandong University, Jinan

310014

NOT_YET_RECRUITING

Zhejiang Provincial People's Hospital, Hangzhou

310016

NOT_YET_RECRUITING

Sir Run Run Shaw Hospital of Zhejiang University School of Medicine, Hangzhou

315010

NOT_YET_RECRUITING

The first affiliated hospital of Ningbo university, Ningbo

325000

NOT_YET_RECRUITING

The First Affiliated Hospital of Wenzhou Medical University, Wenzhou

400030

NOT_YET_RECRUITING

Chongqing University Cancer Hospital, Chongqing

410013

NOT_YET_RECRUITING

Hunan Cancer Hospital, Changsha

510630

NOT_YET_RECRUITING

The Third Affiliated Hospital of Southern Medical University, Guangzhou

710061

NOT_YET_RECRUITING

The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an

1608582

NOT_YET_RECRUITING

Keio university hospital, Shinjuku-ku

G9A 4P3

RECRUITING

Diex Recherche Trois-Rivieres, Trois-Rivières

260-8717

RECRUITING

Chiba cancer center, Chiba

791-0280

NOT_YET_RECRUITING

National Hospital Organization Shikoku Cancer Center, Matsuyama

003-0804

NOT_YET_RECRUITING

National Hospital Organization Hokkaido Cancer Center, Sapporo

060-8648

NOT_YET_RECRUITING

Hokkaido University Hospital, Sapporo

650-0017

NOT_YET_RECRUITING

Kobe University Hospital, Kobe

920-8641

NOT_YET_RECRUITING

Kanazawa University Hospital, Kanazawa

238-8558

RECRUITING

Yokosuka Kyosai Hospital, Yokosuka

565-0871

NOT_YET_RECRUITING

The University of Osaka Hospital, Suita

811-1395

RECRUITING

National Hospital Organization Kyushu Cancer Center, Fukuoka

860-0008

NOT_YET_RECRUITING

National Hospital Organization Kumamoto Medical Center, Kumamoto

541-8567

NOT_YET_RECRUITING

Osaka International Cancer Institute, Osaka

990-9585

NOT_YET_RECRUITING

Yamagata University Hospital, Yamagata

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Pfizer

INDUSTRY

NCT07028853 - This Study Will Explore Whether a Combination of the Investigational Drug Mevrometostat (PF-06821497) and Enzalutamide Will Work Better Than Taking Enzalutamide Alone in Participants With mCSPC Who Are ARPI naïve. | Biotech Hunter | Biotech Hunter