A Study on the Clinical Use of a New Expandable OLIF Cage With Posterior Bone Grafting in Lumbar Spine Surgery

NANot yet recruitingINTERVENTIONAL
Enrollment

340

Participants

Timeline

Start Date

June 10, 2025

Primary Completion Date

June 1, 2026

Study Completion Date

May 31, 2027

Conditions
Lumbar SpondylolisthesisDegenerative Lumbar ScoliosisLumbar Disc HerniationLumbar Spinal Stenosis
Interventions
DEVICE

Expandable OLIF cage with posterior bone grafting

This intervention involves the use of a novel expandable OLIF cage that allows intraoperative height adjustment and posterior bone grafting through a dedicated channel. The device is designed to restore intervertebral height and lumbar lordosis while minimizing endplate injury. Bone grafts (autologous or synthetic) are delivered after expansion to enhance fusion. This design aims to reduce cage subsidence, improve fusion rates, and simplify the surgical workflow compared to conventional OLIF cages with fixed heights.

DEVICE

Conventional OLIF cage

Participants in the control group will undergo oblique lateral interbody fusion (OLIF) using a standard non-expandable interbody fusion cage. The cage has a fixed height and is inserted via the retroperitoneal approach. Bone grafts are packed into the cage prior to insertion through the anterior or lateral window. This represents the current standard practice for OLIF procedures and does not allow intraoperative height adjustment or posterior graft delivery. The procedure follows conventional OLIF surgical protocols without additional design modifications.

All Listed Sponsors
collaborator

The First Affiliated Hospital of Zhengzhou University

OTHER

collaborator

Peking University People's Hospital

OTHER

collaborator

Shanghai Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine

UNKNOWN

collaborator

Jinan Hospital, Xuanwu Hospital, Capital Medical University

UNKNOWN

collaborator

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

OTHER

collaborator

Shanghai changzheng hospital, Naval Medical University

UNKNOWN

lead

The Affiliated Hospital of Qingdao University

OTHER

NCT07028099 - A Study on the Clinical Use of a New Expandable OLIF Cage With Posterior Bone Grafting in Lumbar Spine Surgery | Biotech Hunter | Biotech Hunter