Orelabrutinib Combined With Rituximab as First-line Systemic Treatment for Marginal Zone Lymphoma

PHASE2RecruitingINTERVENTIONAL
Enrollment

51

Participants

Timeline

Start Date

March 11, 2025

Primary Completion Date

September 11, 2027

Study Completion Date

September 11, 2029

Conditions
Marginal Zone Lymphoma(MZL)
Interventions
DRUG

orelabrutinib combined with rituximab regimen

"All participants will receive induction therapy with the orelabrutinib and rituximab regimen. The treatment cycle is 28 days, with a total of 6 cycles. The induction treatment period is as follows:~Cycle 1: Rituximab, 375 mg/m², on Day 1. Cycles 2-6:Orelabrutinib, 150 mg, once daily orally, from Day 1 to Day 28. Rituximab, 375 mg/m², on Day 1.~Patients who achieve a partial response (PR) or better will enter a 2-year maintenance period with orelabrutinib."

Trial Locations (18)

Unknown

RECRUITING

Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou

RECRUITING

Dongyang People's Hospital, Dongyang

RECRUITING

Affiliated Hangzhou First People's Hospital, Hangzhou

RECRUITING

Zhejiang cancer Hospital, Hangzhou

RECRUITING

Huzhou Central Hospital, Huzhou

RECRUITING

Affiliated Hospital of Jiaxing University, Jiaxing

RECRUITING

The Second Affiliated Hospital of Jiaxing University, Jiaxing

RECRUITING

Lishui central Hospital, Lishui

RECRUITING

the Affiliated Peopele'S Hospital of Ningbo University, Ningbo

RECRUITING

Quzhou People's Hospital, Quzhou

RECRUITING

Shaoxing Central Hospital, Shaoxing

RECRUITING

shaoxing People's Hospital, Shaoxing

RECRUITING

Taizhou Central Hospital, Taizhou

RECRUITING

Taizhou First People's Hospital, Taizhou

RECRUITING

Taizhou Hospital ofzhejiang Province, Taizhou

RECRUITING

The Second Affiliated Hospital and Yuying childrens Hospital of Wenzhou Medical University, Wenzhou

RECRUITING

Yuyao People's Hospital, Yuyao

RECRUITING

Affiliated Zhuji Hospital ofWenzhou Medical University, Zhuji

All Listed Sponsors
collaborator

The Second Affiliated Hospital of Jiaxing University

OTHER

collaborator

Taizhou First People's Hospital

OTHER

collaborator

Huzhou Central Hospital

OTHER

collaborator

Zhejiang Cancer Hospital

OTHER

collaborator

Dongyang People's Hospital

OTHER

collaborator

Yuyao People's Hospital

OTHER

collaborator

Taizhou Central Hospital affiliated to Taizhou University

UNKNOWN

collaborator

Shaoxing Central Hospital

OTHER

collaborator

Affiliated Hospital of Jiaxing University

OTHER

collaborator

Shaoxing People's Hospital

OTHER

collaborator

Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University

OTHER

collaborator

The Central Hospital of Lishui City

OTHER

collaborator

Second Affiliated Hospital of Wenzhou Medical University

OTHER

collaborator

Ningbo People's Hospital

UNKNOWN

collaborator

The People's Hospital of Quzhou

OTHER

collaborator

Zhejiang University

OTHER

collaborator

Zhuji People's hospital

UNKNOWN

lead

Second Affiliated Hospital, School of Medicine, Zhejiang University

OTHER