PIN in Combination With Anti-PD1 in Previously Treated Primary Hepatocellular Carcinoma

"1. Initial treatment phase:~ PIN injection frequency:~ day 0 and day 3, per 3 weeks for 8 cycles; PIN injection dosage: Cycle1: 4e9 or 8e9 viral particles of PIN based on the number of injectable lesions, their longest diameter, and the tumor volume capacity .~ Cycle 2\~8: 4e9 or 8e9 viral particles of PIN based on the tumor volume's capacity.~ Anti-PD1: day -3, per 3 weeks for 8 cycles;~2. Maintenance treatment phase:~ No injection lesion: Anti-PD1: day 1, per 3 weeks till 2 years unless PD or serious intolerable AEs.~ Have injection lesion: PIN: 4e9 or 8e9 viral particles based on the tumor volume's capacity, per 6 weeks (within first 24 weeks), then per 8 weeks till 2 years unless unavailability of injection lesion, PD or serious intolerable AEs.~ Anti-PD1: day 1, per 3 weeks till 2 years unless PD or serious intolerable AEs.~3. Salvage treatment phase: Dosage and frequency of administration refer to the initial treatment phase and maintenance treatment phase."