Transcutaneous Auricular Vagus Nerve Stimulation for Persistent Post-concussion Symptoms

NARecruitingINTERVENTIONAL
Enrollment

48

Participants

Timeline

Start Date

May 28, 2025

Primary Completion Date

May 31, 2027

Study Completion Date

June 30, 2027

Conditions
Persistent Post-concussive Symptoms
Interventions
DEVICE

Active taVNS

Patients will receive active taVNS for 15 consecutive days, with each session lasting 30 minutes. The stimulation will target the cymba conchae of the left ear and will consist of alternating 30-second on and 30-second off periods. The current intensity will range from 1 to 3 mA, adjusted to the patient's pain threshold, with a pulse width of 250 μsec and a frequency of 25Hz.

DEVICE

Sham taVNS

Patients will receive sham taVNS for 15 consecutive days, with each session lasting 30 minutes. The stimulation will target the cymba conchae of the left ear and will consist of alternating 30-second on and 30-second off periods. The current intensity will be fixed at 100 µA, with a pulse width of 250 μsec and a frequency of 25 Hz.

Trial Locations (1)

4000

RECRUITING

University Hospital of Liège, Liège

All Listed Sponsors
collaborator

University Hospital Sart Tilman, Liege

UNKNOWN

lead

University of Liege

OTHER

NCT07017257 - Transcutaneous Auricular Vagus Nerve Stimulation for Persistent Post-concussion Symptoms | Biotech Hunter | Biotech Hunter