Neoadjuvant Darovasertib in Primary Uveal Melanoma

PHASE3RecruitingINTERVENTIONAL
Enrollment

520

Participants

Timeline

Start Date

October 31, 2025

Primary Completion Date

October 31, 2030

Study Completion Date

March 31, 2031

Conditions
Uveal Melanoma
Interventions
DRUG

Darovasertib

Dosed orally, twice daily (28-day/ cycle

PROCEDURE

Primary Local Therapy

Plaque Brachytherapy or Enucleation

Trial Locations (75)

168

NOT_YET_RECRUITING

Fondazione Policlinico Universitario A Gemelli - Rome - PPDS, Rome

1090

NOT_YET_RECRUITING

Universitätsklinikum AKH Wien, Vienna

1200

NOT_YET_RECRUITING

Cliniques Universitaires Saint-Luc - PPDS, Brussels

2100

NOT_YET_RECRUITING

Rigshospitalet, Copenhagen O

3000

NOT_YET_RECRUITING

UZ Leuven - PPDS, Leuven

3004

NOT_YET_RECRUITING

The Alfred Hospital, Melbourne

4031

NOT_YET_RECRUITING

Universitätsspital Basel, Basel

5011

NOT_YET_RECRUITING

The Queen Elizabeth Hospital, Woodville South

6000

NOT_YET_RECRUITING

CHU de Nice-Hôpital Pasteur, Nice

6020

NOT_YET_RECRUITING

Universitätsklinikum Innsbruck, Innsbruck

6847

NOT_YET_RECRUITING

Städtisches Klinikum Dessau, Dessau

8036

NOT_YET_RECRUITING

LKH-Universitätsklinikum Graz, Graz

8091

NOT_YET_RECRUITING

Universitätsspital Zürich, Zurich

8200

NOT_YET_RECRUITING

Aarhus Universitetshospital, Aarhus

8907

NOT_YET_RECRUITING

Hospital Universitario de Bellvitge, L'Hospitalet de Llobregat

10032

NOT_YET_RECRUITING

Herbert Irving Comprehensive Cancer Center, New York

11312

NOT_YET_RECRUITING

East Tallinn Central Hospital-Pärnu road 104, Tallinn

12203

NOT_YET_RECRUITING

Charité - Universitätsmedizin Berlin, Berlin

15232

NOT_YET_RECRUITING

UPMC Hillman Cancer Center, Pittsburgh

15706

NOT_YET_RECRUITING

Hospital Clinico Universitario de Santiago, Santiago de Compostela

19107

NOT_YET_RECRUITING

Jefferson Health Honickman Center, Philadelphia

20157

NOT_YET_RECRUITING

ASST Fatebenefratelli Sacco - Ospedale Luigi Sacco, Milan

22939

NOT_YET_RECRUITING

Augusta Health, Center for Cancer and Blood Disorders, Fishersville

23562

NOT_YET_RECRUITING

Universitätsklinikum Schleswig-Holstein - Campus Lübeck, Lübeck

31008

NOT_YET_RECRUITING

Clinica Universidad Navarra, Pamplona

32224

NOT_YET_RECRUITING

Mayo Clinic Jacksonville, Jacksonville

33000

NOT_YET_RECRUITING

Centre Retine Gallien - Bordeaux, Bordeaux

35000

NOT_YET_RECRUITING

CHU de Rennes - Hôpital Pontchaillou, Rennes

35043

NOT_YET_RECRUITING

Universitätsklinikum Giessen und Marburg - Marburg (UKGM), Marburg

37203

NOT_YET_RECRUITING

SCRI Oncology Partners, Nashville

37343

NOT_YET_RECRUITING

Southeastern Retina Associates-Hixson, Hixson

41009

NOT_YET_RECRUITING

Hospital Universitario Virgen Macarena, Seville

43212

NOT_YET_RECRUITING

Ohio State Eye and Ear Institute, Columbus

44195

NOT_YET_RECRUITING

Cole Eye Institute-9500 Euclid Ave, Cleveland

45147

NOT_YET_RECRUITING

Universitätsklinikum Essen, Essen

46026

NOT_YET_RECRUITING

Hospital Universitari i Politecnic La Fe de Valencia, Valencia

47003

NOT_YET_RECRUITING

Hospital Clinico Universitario de Valladolid, Valladolid

48105

NOT_YET_RECRUITING

W Kellogg Eye Center, Ann Arbor

49503

NOT_YET_RECRUITING

The Cancer and Hematology Centers of West Michigan (CHCWM), Grand Rapids

50134

NOT_YET_RECRUITING

Azienda Ospedaliera Universitaria Careggi, Florence

53127

NOT_YET_RECRUITING

Universitätsklinikum Bonn, Bonn

55905

NOT_YET_RECRUITING

Mayo Clinic - PPDS, Rochester

56124

NOT_YET_RECRUITING

Azienda Ospedaliera di Perugia - Ospedale Santa Maria della Misericordia, Pisa

68105

NOT_YET_RECRUITING

TIERING Percentiles, Omaha

72076

NOT_YET_RECRUITING

Universitätsklinikum Tübingen, Tübingen

75231

RECRUITING

Texas Retina Associates - Dallas, Dallas

75248

NOT_YET_RECRUITING

Institut Curie - Hôpital de Paris, Paris

78705

NOT_YET_RECRUITING

Austin Retina Associates - Central, Austin

80045

NOT_YET_RECRUITING

University of Colorado Hospital, Aurora

80131

NOT_YET_RECRUITING

Istituto Nazionale Tumori IRCCS Fondazione Giovanni Pascale, Napoli

85259

NOT_YET_RECRUITING

Mayo Clinic Scottsdale - PPDS, Scottsdale

89075

NOT_YET_RECRUITING

Universitätsklinikum Ulm, Ulm

91120

NOT_YET_RECRUITING

Hadassah Medical Center - PPDS, Jerusalem

92093

NOT_YET_RECRUITING

UCSD Moores Cancer Center, La Jolla

92868

NOT_YET_RECRUITING

University of California Irvine Medical Center, Orange

94304

NOT_YET_RECRUITING

Stanford Comprehensive Cancer Center, Palo Alto

97080

NOT_YET_RECRUITING

Universitätsklinikum Würzburg, Würzburg

5262100

NOT_YET_RECRUITING

The Chaim Sheba Medical Center - PPDS, Ramat Gan

92505-3043

NOT_YET_RECRUITING

Kaiser Permanente-Riverside Medical Center, Riverside

80113-2791

NOT_YET_RECRUITING

The Melanoma and Skin Cancer Institute, Englewood

21287-0005

NOT_YET_RECRUITING

Wilmer Eye Institute, Baltimore

02114

NOT_YET_RECRUITING

Massachusetts Eye and Ear Infirmary, Boston

10065-6635

NOT_YET_RECRUITING

Memorial Sloan Kettering Cancer Center - 1275 York Ave, New York

75390-9057

NOT_YET_RECRUITING

University of Texas Southwestern Medical Center-5323 Harry Hines Blvd, Dallas

53705-3644

NOT_YET_RECRUITING

University of Wisconsin Health, Madison

M5G 2M9

NOT_YET_RECRUITING

Princess Margaret Cancer Centre, Toronto

169 02

NOT_YET_RECRUITING

Ustredni vojenska nemocnice - Vojenska fakultni nemocnice Praha, Prague

715 00

NOT_YET_RECRUITING

PAGNI-University General Hospital of Heraklion, Heraklion

Unknown

NOT_YET_RECRUITING

Azienda Ospedaliera di Perugia - Ospedale Santa Maria della Misericordia, Perugia

3015 GD

NOT_YET_RECRUITING

Erasmus MC, Rotterdam

61-848

NOT_YET_RECRUITING

Uniwersytecki Szpital Kliniczny w Poznaniu- Dluga 1/2, Poznan

04-141

NOT_YET_RECRUITING

WIM-PIB, Centralny Szpital Kliniczny MON, Warsaw

80-214

NOT_YET_RECRUITING

Uniwersyteckie Centrum Kliniczne w Gdansku - Debinki 7, Gdansk

CH63 4JY

NOT_YET_RECRUITING

Clatterbridge Cancer Centre - Liverpool - NWCRN - PPDS, Metropolitan Borough of Wirral

NW1 2BU

NOT_YET_RECRUITING

University College Hospital, London

Sponsors

Lead Sponsor

All Listed Sponsors
lead

IDEAYA Biosciences

INDUSTRY

NCT07015190 - Neoadjuvant Darovasertib in Primary Uveal Melanoma | Biotech Hunter | Biotech Hunter