Relationship Between Remimazolam and Etomidate in Induction of General Anesthesia

EARLY_PHASE1Not yet recruitingINTERVENTIONAL
Enrollment

125

Participants

Timeline

Start Date

June 12, 2025

Primary Completion Date

June 19, 2025

Study Completion Date

July 19, 2025

Conditions
Induction AnesthesiaDrug Interactions
Interventions
DRUG

Etomidate

Group A was induced with etomidate, the initial dose was 0.120mg/kg, and the ratio of adjacent doses was 1:0.6

DRUG

Remimazolam

Group B was induced with remimazolam, the initial dose was 0.20mg/kg, and the ratio of adjacent doses was 1:0.8

DRUG

Remimazolam-etomidate

In group C, 0.25ED50 remimazolam +0.75ED50 etomidate was used as the initial measurement In group D, 0.5ED50 remimazolam +0.5ED50 etomidate was used as the initial measurement In group E, 0.75ED50 of remimazolam +0.25ED50 of etomidate was used as the initial measurement

Trial Locations (1)

030001

Second Hospital of Shanxi Medical University, Taiyuan

All Listed Sponsors
lead

Second Hospital of Shanxi Medical University

OTHER