A EUROpean Randomized Study on Blood-thinners and Cholesterol-lowering Treatments to Prevent Future Vascular Events in People With Covert Brain Infarcts (CBI)

PHASE3Not yet recruitingINTERVENTIONAL
Enrollment

1,652

Participants

Timeline

Start Date

September 1, 2025

Primary Completion Date

September 30, 2031

Study Completion Date

January 1, 2040

Conditions
Covert Brain Infarction
Interventions
DRUG

acetylsalicyclic acid (ASA)

Daily dose 75 mg to 100 mg p.o.

DRUG

Clopidogrel

Daily dose 75 mg p.o.

DRUG

Rosuvastatin

"Daily dose 20 mg p.o. (10 mg once daily for the first 4 weeks, then 20 mg once daily for the remainder of the study period if tolerated).~If Rosuvastatin 20 mg is not tolerated, a dose reduction to 10 mg is allowed."

DRUG

Atorvastatin

Daily dose 40 mg p.o. If Atorvastatin 40 mg is not tolerated, a dose reduction to 20 mg is allowed.

Trial Locations (14)

2100

Rigshospitalet, Copenhagen

2400

Bispebjerg og Frederiksberg Hospital, Copenhagen

2730

Herlev Hospital, Herlev

3010

Universitätsspital - Inselspital - University of Bern, Bern

4000

Roskilde Hospital, Roskilde

5000

Odense Universitetshospital, Odense

6000

Kolding Hospital, Kolding

7400

Regionshospitalet Gødstrup, Herning

8200

Aarhus Universitetshospital, Aarhus

Aarhus University Hospital, Aarhus

9000

Aalborg Universitetshospital, Aalborg

20246

University Medical Center Hamburg-Eppendorf, Hamburg

22242

Skånes Universitetssjukhus, Lund

0450

Oslo University Hospital, Oslo

All Listed Sponsors
collaborator

Rigshospitalet, Denmark

OTHER

collaborator

Bispebjerg Hospital

OTHER

collaborator

Herlev Hospital

OTHER

collaborator

Zealand University Hospital

OTHER

collaborator

Odense University Hospital

OTHER

collaborator

Aalborg University Hospital

OTHER

collaborator

Gødstrup Hospital

OTHER

collaborator

Oslo University Hospital

OTHER

collaborator

University Medical Center Hamburg-Eppendorf (UKE)

UNKNOWN

collaborator

Insel Gruppe AG, University Hospital Bern

OTHER

collaborator

Lund University Hospital

OTHER

lead

Aarhus University Hospital

OTHER