Identifying the Best Flow Setting Strategy for High-Flow Nasal Cannula

NARecruitingINTERVENTIONAL
Enrollment

480

Participants

Timeline

Start Date

June 5, 2025

Primary Completion Date

June 30, 2028

Study Completion Date

June 30, 2028

Conditions
Extubation ReadinessRespiratory Failure With Hypoxia
Interventions
OTHER

Flow of 40L/min

Setting flow rate at 40L/min

OTHER

Peak tidal inspiratory flow (PTIF) guided

Setting HFNC flow at 5 L/min above the peak tidal inspiratory flow (PTIF), up to a maximum of 60 L/min.

OTHER

PaO2/FiO2 ratio guided

Setting HFNC flow according to P/F ratio prior to extubation. Flow will be set at 60, 50 40 L/min if P/F ratio \<250 mmHg, 250-300 mmHg and \>300 mmHg, respectively.

OTHER

Flow of 60L/min

Setting flow rate at 60L/min

Trial Locations (1)

Unknown

RECRUITING

National Taiwan University Hospital, Taipei

All Listed Sponsors
lead

National Taiwan University Hospital

OTHER

NCT07007715 - Identifying the Best Flow Setting Strategy for High-Flow Nasal Cannula | Biotech Hunter | Biotech Hunter