Early Aggressive Strategy for Treatment of Lipid-Lowering in Acute Ischemic Stroke Delivered With Endovascular Therapy for Large Artery Occlusion

PHASE3Not yet recruitingINTERVENTIONAL
Enrollment

652

Participants

Timeline

Start Date

June 30, 2025

Primary Completion Date

June 1, 2028

Study Completion Date

January 1, 2029

Conditions
Stroke
Interventions
DRUG

guideline-recommended SoC

Guideline-recommended SoC, including but not limited to oral lipid-lowering drugs, antiplatelet aggregation drugs, anticoagulant drugs, antihypertensive drugs, etc. It is to be determined by the investigator based on the subject's treatment needs.

DRUG

Recaticimab (intensive)

Recaticimab is added to the guideline-recommended SoC. After randomization and before endovascular interventional treatment, patients will receive a subcutaneous injection of Recaticimab. The specific method is: Recaticimab 450 mg (3 vials) as a single subcutaneous injection, until the end of the follow-up for this study.

Trial Locations (1)

200127

Shanghai East Hospital, Tongji University, Shanghai

All Listed Sponsors
lead

Shanghai East Hospital

OTHER