A Study to Investigate Ataciguat for Slowing the Progression of Moderate Calcific Aortic Valve Stenosis

PHASE3RecruitingINTERVENTIONAL
Enrollment

1,410

Participants

Timeline

Start Date

June 27, 2025

Primary Completion Date

August 31, 2028

Study Completion Date

September 30, 2030

Conditions
Moderate Aortic Valve Stenosis
Interventions
DRUG

Ataciguat

Ataciguat will be administrated daily for up to 156 weeks

DRUG

Placebo

Placebo will be administrated daily for up to 156 weeks

Trial Locations (47)

10467

NOT_YET_RECRUITING

Montefiore Medical Center, The Bronx

12208

NOT_YET_RECRUITING

Albany Medical Center, Albany

14203

NOT_YET_RECRUITING

University of Buffalo, Buffalo

15213

NOT_YET_RECRUITING

University of Pittsburgh Medical Center, Pittsburgh

19104

NOT_YET_RECRUITING

University of Pennsylvania, Philadelphia

21201

NOT_YET_RECRUITING

University of Maryland Medical Center, Baltimore

21287

NOT_YET_RECRUITING

Johns Hopkins University School of Medicine, Baltimore

27401

NOT_YET_RECRUITING

Moses H. Cone Memorial Hospital Operating Corporation d/b/a Cone Health, Greensboro

27710

NOT_YET_RECRUITING

Duke University School of Medicine, Durham

29425

NOT_YET_RECRUITING

Medical University of South Carolina (MUSC), Charleston

33016

RECRUITING

New Generation of Medical Research, Hialeah

33462

NOT_YET_RECRUITING

HCA Florida - JFK Hospital, Atlantis

33606

NOT_YET_RECRUITING

University of South Florida, Tampa

34116

NOT_YET_RECRUITING

New Generation of Medical Research - Naples, Naples

34239

NOT_YET_RECRUITING

Sarasota Memorial Hospital, Sarasota

35233

NOT_YET_RECRUITING

University of Alabama at Birmingham (UAB) - Medical Center, Birmingham

35801

RECRUITING

Heart Center Research LLC, Huntsville

37205

NOT_YET_RECRUITING

Ascension Saint Thomas Heart Midtown, Nashville

37232

NOT_YET_RECRUITING

Vanderbilt University Medical Center, Nashville

40202

NOT_YET_RECRUITING

University of Louisville Health, Louisville

44195

RECRUITING

Cleveland Clinic, Cleveland

45219

NOT_YET_RECRUITING

The Lindner Center for Research and Education at The Christ Hospital, Cincinnati

46290

NOT_YET_RECRUITING

St. Vincent Medical Group, Inc., Carmel

48073

NOT_YET_RECRUITING

Corewell Health, Royal Oak

48322

RECRUITING

Henry Ford Hospital, West Bloomfield

52242

NOT_YET_RECRUITING

University of Iowa Health Care, Iowa City

55905

NOT_YET_RECRUITING

Mayo Clinic - Rochester, Rochester

58122

NOT_YET_RECRUITING

Sanford Fargo, Fargo

60026

NOT_YET_RECRUITING

NorthShore University Health System, Glenview

60611

NOT_YET_RECRUITING

Northwestern University The Feinberg School of Medicine, Chicago

62701

RECRUITING

Prairie Education and Research Cooperative, Springfield

63110

NOT_YET_RECRUITING

Washington University, St Louis

67226

RECRUITING

Cardiovascular Consultants of Kansas, P.A., Wichita

74006

RECRUITING

Ascension St. John Jane Phillips Hospital, Bartlesville

74104

RECRUITING

Ascension St. John Hospital, Tulsa

75093

NOT_YET_RECRUITING

Baylor Scott and White - The Heart Hospital Baylor Plano, Plano

77030

NOT_YET_RECRUITING

Houston Methodist Hospital, Houston

78229

NOT_YET_RECRUITING

Methodist Hospital - San Antonio, San Antonio

78705

NOT_YET_RECRUITING

St. David's Heart and Vascular dba Austin Heart - Main Office, Austin

84112

NOT_YET_RECRUITING

University of Utah Hospital & Clinics, Salt Lake City

90211

RECRUITING

National Heart Institute, Beverly Hills

90502

NOT_YET_RECRUITING

Lundquist Institute for Biomedical Innovation at Harbor UCLA Medical Center, Torrance

91105

NOT_YET_RECRUITING

Profound Research LLC at Southern California Heart Specialists, Pasadena

92663

NOT_YET_RECRUITING

Hoag Memorial Hospital Presbyterian, Newport Beach

94143

NOT_YET_RECRUITING

University of California, San Francisco (UCSF) - Medical Center, San Francisco

02114

NOT_YET_RECRUITING

Massachusetts General Hospital, Boston

02115

NOT_YET_RECRUITING

Brigham and Women's Hospital, Boston

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Kardigan, Inc.

INDUSTRY

NCT07001800 - A Study to Investigate Ataciguat for Slowing the Progression of Moderate Calcific Aortic Valve Stenosis | Biotech Hunter | Biotech Hunter