Quadriceps Motor Unit Adaptation to Simulated Knee Injury

NANot yet recruitingINTERVENTIONAL
Enrollment

45

Participants

Timeline

Start Date

August 1, 2025

Primary Completion Date

June 1, 2026

Study Completion Date

June 1, 2026

Conditions
Muscle InhibitionKnee Injury Simulation
Interventions
DEVICE

Joint Effusion via 60 mL Sterile Saline

Injection of sterile saline into the knee joint to simulate joint swelling and induce quadriceps inhibition.

DRUG

Intra-articular Lidocaine

Injection of 7 mL lidocaine into the knee joint to simulate deafferentation by temporarily blocking sensory input.

OTHER

Sham injection

Simulated knee injection using a stage needle without skin penetration, used to blind participants and serve as control.

All Listed Sponsors
lead

University of Central Florida

OTHER

NCT06999057 - Quadriceps Motor Unit Adaptation to Simulated Knee Injury | Biotech Hunter | Biotech Hunter