the Impact of Transcutaneous Vagus Nerve Stimulation on Cardiovascular Events in Patients With Acute Myocardial Infarction

NANot yet recruitingINTERVENTIONAL
Enrollment

278

Participants

Timeline

Start Date

June 1, 2025

Primary Completion Date

June 1, 2028

Study Completion Date

October 1, 2028

Conditions
Acute Myocardial Infarction (AMI)
Interventions
DEVICE

transcutaneous vagus nerve stimulation

The stimulation times are fixed between 07:00-09:00 in the morning and 19:00-21:00 in the evening, with an interval of 12 hours between the two sessions. The device is set with a pulse width of 200 microseconds and a pulse frequency of 20 hertz. The stimulation intensity is individually adjusted to above the perception threshold and below the discomfort level of 1 milliampere.

DEVICE

Sham (no implant)

Vagus nerve stimulation is delivered through a transcutaneous electrical nerve stimulation device by attaching an ear clip to the tragus. But no stimulation will be delivered. The sham stimulation will be performed twice daily, each session lasting for half an hour. The stimulation times are fixed between 07:00-09:00 in the morning and 19:00-21:00 in the evening, with an interval of 12 hours between the two sessions.

All Listed Sponsors
lead

Shanghai East Hospital

OTHER

NCT06991283 - the Impact of Transcutaneous Vagus Nerve Stimulation on Cardiovascular Events in Patients With Acute Myocardial Infarction | Biotech Hunter | Biotech Hunter