Endogenous Oxalate Synthesis in Idiopathic Calcium Oxalate Kidney Stone Disease

NARecruitingINTERVENTIONAL
Enrollment

80

Participants

Timeline

Start Date

May 27, 2025

Primary Completion Date

December 31, 2030

Study Completion Date

December 31, 2031

Conditions
Kidney StonesKidney CalculiUrolithiasisUrolithiasis, Calcium OxalateNephrolithiasisNephrolithiasis, Calcium OxalateOxalate UrolithiasisHealthyHealthy Volunteer
Interventions
DIETARY_SUPPLEMENT

Low-oxalate diet and glycolate dosing

Low-oxalate diet 4 days of fixed eucaloric diet with low oxalate (\<60 mg/day), normal calcium content (600-1000 mg/day)

DIETARY_SUPPLEMENT

Oral glycolate dosing

Oral 13C-glycolate dosing (0.5 mg/kg)

DIETARY_SUPPLEMENT

Oral 13C- ascorbic acid dosing

Oral 13C- ascorbic acid dosing (0.75 mg/kg)

Trial Locations (2)

35294

RECRUITING

United States, Alabama University of Alabama at Birmingham, Birmingham

75390

NOT_YET_RECRUITING

University of Texas South Western Medical Center, Dallas

All Listed Sponsors
collaborator

University of Texas, Southwestern Medical Center at Dallas

OTHER

collaborator

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NIH

lead

University of Alabama at Birmingham

OTHER