DESTINY-Endometrial01: A Phase III Study of Trastuzumab Deruxtecan Plus Rilvegostomig or Pembrolizumab as First-Line Treatment of HER2-Expressing (IHC 3+/2+), Mismatch Repair Proficient (pMMR) Endometrial Cancer

PHASE3RecruitingINTERVENTIONAL
Enrollment

600

Participants

Timeline

Start Date

March 27, 2025

Primary Completion Date

January 19, 2029

Study Completion Date

February 19, 2031

Conditions
Endometrial Cancer
Interventions
DRUG

Trastuzumab deruxtecan

Experimental therapy by intravenous infusion

DRUG

Rilvegostomig

Experimental therapy by intravenous infusion

DRUG

Pembrolizumab

Immunotherapy by intravenous infusion

DRUG

Carboplatin

Standard of Care (SoC) chemotherapy by intravenous infusion

DRUG

Paclitaxel

Standard of Care (SoC) chemotherapy by intravenous infusion

DRUG

Docetaxel

Standard of Care (SoC) chemotherapy by intravenous infusion

Trial Locations (244)

220

RECRUITING

Research Site, New Taipei City

500

RECRUITING

Research Site, Changhua

704

RECRUITING

Research Site, Tainan City

1070

NOT_YET_RECRUITING

Research Site, Anderlecht

1088

NOT_YET_RECRUITING

Research Site, Budapest

1090

NOT_YET_RECRUITING

Research Site, Vienna

1122

NOT_YET_RECRUITING

Research Site, Budapest

1130

NOT_YET_RECRUITING

Research Site, Wein

1200

NOT_YET_RECRUITING

Research Site, Brussels

1409

NOT_YET_RECRUITING

Research Site, São Paulo

2100

NOT_YET_RECRUITING

Research Site, København Ø

2148

RECRUITING

Research Site, Blacktown

2730

WITHDRAWN

Research Site, Herlev

3000

NOT_YET_RECRUITING

Research Site, Leuven

3002

RECRUITING

Research Site, East Melbourne

4000

NOT_YET_RECRUITING

Research Site, Liège

4011

NOT_YET_RECRUITING

Research Site, Stavanger

4021

NOT_YET_RECRUITING

Research Site, Linz

4032

RECRUITING

Research Site, Debrecen

4101

RECRUITING

Research Site, South Brisbane

5000

NOT_YET_RECRUITING

Research Site, Odense

6009

RECRUITING

Research Site, Nedlands

6020

NOT_YET_RECRUITING

Research Site, Innsbruck

6060

WITHDRAWN

Research Site, Charleroi

8091

NOT_YET_RECRUITING

Research Site, Zurich

8501

WITHDRAWN

Research Site, Frauenfeld

9000

NOT_YET_RECRUITING

Research Site, Ghent

9007

NOT_YET_RECRUITING

Research Site, Sankt Gallen

9100

NOT_YET_RECRUITING

Research Site, Aalborg

10016

WITHDRAWN

Research Site, New York

10065

NOT_YET_RECRUITING

Research Site, New York

10075

WITHDRAWN

Research Site, New York

10128

NOT_YET_RECRUITING

Research Site, Torino

NOT_YET_RECRUITING

Research Site, Turin

10408

RECRUITING

Research Site, Goyang-si

10449

RECRUITING

Research Site, Taipei

13353

NOT_YET_RECRUITING

Research Site, Berlin

14004

NOT_YET_RECRUITING

Research Site, Córdoba

14076

NOT_YET_RECRUITING

Research Site, Caen

15009

NOT_YET_RECRUITING

Research Site, A Coruña

15224

NOT_YET_RECRUITING

Research Site, Pittsburgh

16499

RECRUITING

Research Site, Suwon

17033

WITHDRAWN

Research Site, Hershey

17164

NOT_YET_RECRUITING

Research Site, Stockholm

19001

WITHDRAWN

Research Site, Abington

19111

NOT_YET_RECRUITING

Research Site, Philadelphia

20014

NOT_YET_RECRUITING

Research Site, Donostia / San Sebastian

20141

NOT_YET_RECRUITING

Research Site, Milan

20159

NOT_YET_RECRUITING

Research Site, Milan

20162

NOT_YET_RECRUITING

Research Site, Milan

20246

NOT_YET_RECRUITING

Research Site, Hamburg

20520

NOT_YET_RECRUITING

Research Site, Turku

20900

NOT_YET_RECRUITING

Research Site, Monza

21201

NOT_YET_RECRUITING

Research Site, Baltimore

22031

NOT_YET_RECRUITING

Research Site, Fairfax

22185

NOT_YET_RECRUITING

Research Site, Lund

22190

NOT_YET_RECRUITING

Research Site, Plérin

22908

RECRUITING

Research Site, Charlottesville

25030

NOT_YET_RECRUITING

Research Site, Besançon

27103

RECRUITING

Research Site, Winston-Salem

28034

NOT_YET_RECRUITING

Research Site, Madrid

28041

NOT_YET_RECRUITING

Research Site, Madrid

28204

RECRUITING

Research Site, Charlotte

29425

NOT_YET_RECRUITING

Research Site, Charleston

30120

NOT_YET_RECRUITING

Research Site, El Palmar

30912

NOT_YET_RECRUITING

Research Site, Augusta

31059

NOT_YET_RECRUITING

Research Site, Toulouse

33076

NOT_YET_RECRUITING

Research Site, Bordeaux

33140

NOT_YET_RECRUITING

Research Site, Miami Beach

33401

NOT_YET_RECRUITING

Research Site, West Palm Beach

33520

NOT_YET_RECRUITING

Research Site, Tampere

33612

NOT_YET_RECRUITING

Research Site, Tampa

33705

NOT_YET_RECRUITING

Research Site, St. Petersburg

33901

NOT_YET_RECRUITING

Research Site, Fort Myers

34125

NOT_YET_RECRUITING

Research Site, Kassel

34298

NOT_YET_RECRUITING

Research Site, Montpellier

35043

NOT_YET_RECRUITING

Research Site, Marburg

39216

NOT_YET_RECRUITING

Research Site, Jackson

40705

RECRUITING

Research Site, Taichung

43210

NOT_YET_RECRUITING

Research Site, Columbus

44805

NOT_YET_RECRUITING

Research Site, Saint-Herblain

45147

NOT_YET_RECRUITING

Research Site, Essen

45220

NOT_YET_RECRUITING

Research Site, Cincinnati

46006

NOT_YET_RECRUITING

Research Site, Valencia

46009

NOT_YET_RECRUITING

Research Site, Valencia

48109

NOT_YET_RECRUITING

Research Site, Ann Arbor

48149

NOT_YET_RECRUITING

Research Site, Münster

48201

WITHDRAWN

Research Site, Detroit

50009

NOT_YET_RECRUITING

Research Site, Zaragoza

50134

NOT_YET_RECRUITING

Research Site, Florence

53705

NOT_YET_RECRUITING

Research Site, Madison

55455

NOT_YET_RECRUITING

Research Site, Minneapolis

55905

NOT_YET_RECRUITING

Research Site, Rochester

57105

RECRUITING

Research Site, Sioux Falls

60005

NOT_YET_RECRUITING

Research Site, Arlington Heights

60201

NOT_YET_RECRUITING

Research Site, Evanston

63000

NOT_YET_RECRUITING

Research Site, Clermont-Ferrand

63141

NOT_YET_RECRUITING

Research Site, St Louis

65804

NOT_YET_RECRUITING

Research Site, Springfield

66113

NOT_YET_RECRUITING

Research Site, Saarbrücken

68167

NOT_YET_RECRUITING

Research Site, Mannheim

69373

NOT_YET_RECRUITING

Research Site, Lyon

71103

RECRUITING

Research Site, Shreveport

72205

NOT_YET_RECRUITING

Research Site, Little Rock

74134

WITHDRAWN

Research Site, Tulsa

75015

NOT_YET_RECRUITING

Research Site, Paris

76104

NOT_YET_RECRUITING

Research Site, Fort Worth

77030

NOT_YET_RECRUITING

Research Site, Houston

78240

NOT_YET_RECRUITING

Research Site, San Antonio

78758

NOT_YET_RECRUITING

Research Site, Austin

80131

NOT_YET_RECRUITING

Research Site, Napoli

81362

RECRUITING

Research Site, Kaohsiung City

85704

WITHDRAWN

Research Site, Tucson

86021

NOT_YET_RECRUITING

Research Site, Poitiers

87109

NOT_YET_RECRUITING

Research Site, Albuquerque

89169

WITHDRAWN

Research Site, Las Vegas

90029

NOT_YET_RECRUITING

Research Site, Oulu

91010

NOT_YET_RECRUITING

Research Site, Duarte

91342

WITHDRAWN

Research Site, Sylmar

92037

NOT_YET_RECRUITING

Research Site, La Jolla

94143

NOT_YET_RECRUITING

Research Site, San Francisco

94304

WITHDRAWN

Research Site, Palo Alto

95100

NOT_YET_RECRUITING

Research Site, Catania

96813

WITHDRAWN

Research Site, Honolulu

97401

NOT_YET_RECRUITING

Research Site, Eugene

98133

WITHDRAWN

Research Site, Seattle

100142

RECRUITING

Research Site, Beijing

110004

NOT_YET_RECRUITING

Research Site, Shenyang

110042

NOT_YET_RECRUITING

Research Site, Shenyang

130021

NOT_YET_RECRUITING

Research Site, Changchun

150049

NOT_YET_RECRUITING

Research Site, Harbin

200011

RECRUITING

Research Site, Shanghai

201318

RECRUITING

Research Site, Shanghai

221009

RECRUITING

Research Site, Xuzhou

230001

RECRUITING

Research Site, Hefei

250021

RECRUITING

Research Site, Jinan

250117

RECRUITING

Research Site, Jinan

272029

RECRUITING

Research Site, Jining

300060

RECRUITING

Research Site, Tianjin

310022

RECRUITING

Research Site, Hangzhou

330006

RECRUITING

Research Site, Nanchang

350001

RECRUITING

Research Site, Fuzhou

350014

NOT_YET_RECRUITING

Research Site, Fuzhou

400030

RECRUITING

Research Site, Chongqing

410013

RECRUITING

Research Site, Changsha

422122

NOT_YET_RECRUITING

Research Site, Reggio Emilia

430000

RECRUITING

Research Site, Wuhan

430022

RECRUITING

Research Site, Wuhan

510060

RECRUITING

Research Site, Guangzhou

510080

RECRUITING

Research Site, Guangzhou

510120

RECRUITING

Research Site, Guangzhou

530021

RECRUITING

Research Site, Nanning

570311

RECRUITING

Research Site, Haikou

610041

RECRUITING

Research Site, Chengdu

610072

RECRUITING

Research Site, Chengdu

610500

NOT_YET_RECRUITING

Research Site, Yibin

650118

RECRUITING

Research Site, Kunming

710061

RECRUITING

Research Site, Xi'an

730030

RECRUITING

Research Site, Lanzhou

830000

WITHDRAWN

Research Site, Ürümqi

90610000

NOT_YET_RECRUITING

Research Site, Porto Alegre

02111

NOT_YET_RECRUITING

Research Site, Boston

01655

NOT_YET_RECRUITING

Research Site, Worcester

07601

NOT_YET_RECRUITING

Research Site, Hackensack

02905

NOT_YET_RECRUITING

Research Site, Providence

05819

NOT_YET_RECRUITING

Research Site, Saint Johnsbury

14784-057

NOT_YET_RECRUITING

Research Site, Barretos

30130 100

NOT_YET_RECRUITING

Research Site, Belo Horizonte

74000-000

RECRUITING

Research Site, Goiânia

86015-520

NOT_YET_RECRUITING

Research Site, Londrina

90020-090

NOT_YET_RECRUITING

Research Site, Porto Alegre

20220-410

NOT_YET_RECRUITING

Research Site, Rio de Janeiro

41.950-610

NOT_YET_RECRUITING

Research Site, Salvador

01246-000

NOT_YET_RECRUITING

Research Site, São Paulo

01317-001

NOT_YET_RECRUITING

Research Site, São Paulo

64049-200

NOT_YET_RECRUITING

Research Site, Teresina

T2N 5G2

RECRUITING

Research Site, Calgary

T6G 1Z2

NOT_YET_RECRUITING

Research Site, Edmonton

R3E 0V9

NOT_YET_RECRUITING

Research Site, Winnipeg

B3H 2Y9

WITHDRAWN

Research Site, Halifax

N6A 4L6

RECRUITING

Research Site, London

M4N 3M5

NOT_YET_RECRUITING

Research Site, Toronto

M5G 2M9

RECRUITING

Research Site, Toronto

H1T 2M4

RECRUITING

Research Site, Montreal

H2X 0A9

RECRUITING

Research Site, Montreal

H3G 1A4

RECRUITING

Research Site, Montreal

G1J 4Z1

RECRUITING

Research Site, Québec

Unknown

RECRUITING

Research Site, Shantou

030001

RECRUITING

Research Site, Taiyuan

00290

NOT_YET_RECRUITING

Research Site, Helsinki

06100

NOT_YET_RECRUITING

Research Site, Nice

09116

NOT_YET_RECRUITING

Research Site, Chemnitz

06847

NOT_YET_RECRUITING

Research Site, Dessau

01307

NOT_YET_RECRUITING

Research Site, Dresden

04103

NOT_YET_RECRUITING

Research Site, Leipzig

00144

NOT_YET_RECRUITING

Research Site, Roma

00168

NOT_YET_RECRUITING

Research Site, Rome

673-8558

NOT_YET_RECRUITING

Research Site, Akashi-shi

901-2725

RECRUITING

Research Site, Ginowan-shi

350-1298

NOT_YET_RECRUITING

Research Site, Hidaka-shi

259-1193

RECRUITING

Research Site, Isehara-shi

227-8577

NOT_YET_RECRUITING

Research Site, Kashiwa

277-8567

NOT_YET_RECRUITING

Research Site, Kashiwa-shi

650-0047

NOT_YET_RECRUITING

Research Site, Kobe

135-8550

RECRUITING

Research Site, Kōtoku

830-0011

RECRUITING

Research Site, Kurume-shi

791-0280

RECRUITING

Research Site, Matsuyama

028-3695

RECRUITING

Research Site, Morioka

464-8681

NOT_YET_RECRUITING

Research Site, Nagoya

951-8520

RECRUITING

Research Site, Niigata

541-8567

NOT_YET_RECRUITING

Research Site, Osaka

373-8550

RECRUITING

Research Site, Ota-shi

060-8638

RECRUITING

Research Site, Sapporo

980-8574

NOT_YET_RECRUITING

Research Site, Sendai

160-8582

RECRUITING

Research Site, Shinjuku-ku

411-8777

NOT_YET_RECRUITING

Research Site, Sunto-gun

104-0045

RECRUITING

Research Site, Tokyo

1066CX

WITHDRAWN

Research Site, Amsterdam

2333 ZA

WITHDRAWN

Research Site, Leiden

6525 GA

WITHDRAWN

Research Site, Nijmegen

3015 GD

WITHDRAWN

Research Site, Rotterdam

0379

NOT_YET_RECRUITING

Research Site, Oslo

15-027

NOT_YET_RECRUITING

Research Site, Bialystok

80-214

NOT_YET_RECRUITING

Research Site, Gdansk

93-338

NOT_YET_RECRUITING

Research Site, Lodz

60-569

NOT_YET_RECRUITING

Research Site, Poznan

08-110

NOT_YET_RECRUITING

Research Site, Siedlce

70-111

NOT_YET_RECRUITING

Research Site, Szczecin

03080

RECRUITING

Research Site, Seoul

03722

RECRUITING

Research Site, Seoul

05505

RECRUITING

Research Site, Seoul

06351

RECRUITING

Research Site, Seoul

08908

NOT_YET_RECRUITING

Research Site, L'Hospitalet de Llobregat

07010

NOT_YET_RECRUITING

Research Site, Palma de Mallorca

581 85

NOT_YET_RECRUITING

Research Site, Linköping

751 85

NOT_YET_RECRUITING

Research Site, Uppsala

CH- 4410

NOT_YET_RECRUITING

Research Site, Liestal

BA1 3NG

NOT_YET_RECRUITING

Research Site, Bath

CB2 0QQ

NOT_YET_RECRUITING

Research Site, Cambridge

LS9 7TF

NOT_YET_RECRUITING

Research Site, Leeds

EC1A 7BE

NOT_YET_RECRUITING

Research Site, London

M20 4BX

NOT_YET_RECRUITING

Research Site, Manchester

HA6 2RN

NOT_YET_RECRUITING

Research Site, Northwood

TA1 5DA

NOT_YET_RECRUITING

Research Site, Taunton

Sponsors

Lead Sponsor

Collaborators (1)

All Listed Sponsors
collaborator

Daiichi Sankyo Co., Ltd.

INDUSTRY

collaborator

Gynecologic Oncology Group (GOG) Foundation Inc.

UNKNOWN

collaborator

European Network for Gynaecological Oncological Trial groups(ENGOT)

UNKNOWN

lead

AstraZeneca

INDUSTRY

NCT06989112 - DESTINY-Endometrial01: A Phase III Study of Trastuzumab Deruxtecan Plus Rilvegostomig or Pembrolizumab as First-Line Treatment of HER2-Expressing (IHC 3+/2+), Mismatch Repair Proficient (pMMR) Endometrial Cancer | Biotech Hunter | Biotech Hunter