Continuous Renal Replacement Therapy Intensity in Hyperammonemia

NAEnrolling by invitationINTERVENTIONAL
Enrollment

152

Participants

Timeline

Start Date

March 14, 2025

Primary Completion Date

May 14, 2029

Study Completion Date

May 14, 2029

Conditions
Acute Liver FailureAcute on Chronic Liver Failure (ACLF)Acute Kidney InjuryAmmonia Metabolism
Interventions
DEVICE

High-dose continuous renal replacement therapy

Continuous renal replacement therapy administered at an effluent dose of 45-55 mL/kg/h using standard equipment and protocols for critically ill patients with ALF or ACLF and hyperammonemia.

DEVICE

Conventional-dose continuous renal replacement therapy

Continuous renal replacement therapy administered at an effluent dose of 25-35 mL/kg/h using standard equipment and protocols for critically ill patients with ALF or ACLF and hyperammonemia.

Trial Locations (1)

90410-000

Hospital de Clinicas de Porto Alegre, Porto Alegre

All Listed Sponsors
collaborator

FIPE - Fundo de Incentivo a Pesquisa do Hospital de Clínicas de Porto Alegre

UNKNOWN

lead

Hospital de Clinicas de Porto Alegre

OTHER