ZeroHeart Biopsy - Prediction of Deceased Donor Heart Transplant Performance From Organ Donors Using Pre-Transplant Biopsies - A Pilot Study

RecruitingOBSERVATIONAL
Enrollment

50

Participants

Timeline

Start Date

May 12, 2025

Primary Completion Date

May 31, 2027

Study Completion Date

May 31, 2028

Conditions
Heart TransplantationGraft RejectionMyocardial InjuryOrgan PreservationBiopsyGene Expression Profiling
Interventions
DIAGNOSTIC_TEST

Time Zero Donor Heart Biopsy for Molecular Analysis

"This intervention involves obtaining a right ventricular myocardial biopsy from the donor heart at the time of organ procurement (Time Zero), prior to transplantation. The biopsy is divided into two parts: one for routine histopathological evaluation and the other preserved in RNAlater® for molecular analysis using microarray technology. This molecular profiling is designed to detect early tissue injury and gene expression patterns associated with graft viability and transplant outcomes. The intervention is performed only once per donor and does not alter the standard clinical care of the recipient."

Trial Locations (1)

1090

RECRUITING

Medical University Vienna, Vienna

All Listed Sponsors
collaborator

Alberta Transplant Applied Genomics Centre

UNKNOWN

lead

Medical University of Vienna

OTHER