Pembrolizumab + Paclitaxel +/- Bevacizumab for Triple-negative Breast Cancer

PHASE2RecruitingINTERVENTIONAL
Enrollment

44

Participants

Timeline

Start Date

July 31, 2025

Primary Completion Date

September 30, 2028

Study Completion Date

September 30, 2028

Conditions
Recurrent Triple-Negative Breast Cancer
Interventions
DRUG

Pembrolizumab

"Protocol treatment will continue until worsening of the participant's underlying disease or unacceptable toxicity is observed or the participant withdraws the consent, or the participant meets other discontinuation criteria.~Pembrolizumab: Intravenous infusion(400 mg/body, every 6 weeks starting on Day 1 of Cycle 1)"

DRUG

Paclitaxel

"Protocol treatment will continue until worsening of the participant's underlying disease or unacceptable toxicity is observed or the participant withdraws the consent, or the participant meets other discontinuation criteria.~Paclitaxel: Intravenous infusion(90 mg/m\^2, on Days 1, 8, and 15, starting on Day 1 of Cycle 1 with a 28-day cycle)"

DRUG

Bevacizumab

"Protocol treatment will continue until worsening of the participant's underlying disease or unacceptable toxicity is observed or the participant withdraws the consent, or the participant meets other discontinuation criteria.~Bevacizumabl: Intravenous infusion(10 mg/kg, on Days 1, and 15, starting on Day 1 of Cycle 1 with a 28-day cycle)"

Trial Locations (15)

460-0001

RECRUITING

National Hospital Organization Nagoya Medical Center, Nagoya

466-8560

RECRUITING

Nagoya University Hospital, Nagoya

467-8602

NOT_YET_RECRUITING

Nagoya City University Hospital, Nagoya

010-8543

NOT_YET_RECRUITING

Akita University Hospital, Akita

277-8577

NOT_YET_RECRUITING

National Cancer Center Hospital East, Kashiwa-shi

501-1194

RECRUITING

Gifu University Hospital, Gifu

734-8551

NOT_YET_RECRUITING

Hiroshima University Hospital, Hiroshima

060-8648

RECRUITING

Hokkaido University Hospital, Sapporo

673-8558

RECRUITING

Hyogo Cancer Center, Akashi-shi

700-8558

RECRUITING

Okayama University Hospital, Okayama

541-8567

RECRUITING

Osaka International Cancer Institute, Osaka

545-0051

NOT_YET_RECRUITING

Osaka Metropolitan University Hospital, Osaka

589-8511

NOT_YET_RECRUITING

Kindai University Hospital, Sayama-shi

135-8550

RECRUITING

Cancer Institute Hospital of JFCR, Koto-ku

142-8666

RECRUITING

SHOWA Medical University Hospital, Shinagawa-ku

All Listed Sponsors
collaborator

Merck Sharp & Dohme LLC

INDUSTRY

lead

Yukinori Ozaki

OTHER