High-dose Topotecan for Retinoblastoma With Recurrent or Refractory Vitreous Seed

Intravitreal injection of topotecan at a dosage of 100μg was performed at week 1.Then based on the tumor response and vitreous seeding, it will be decided whether to continue the injection by ophthalmologists.

Patients' aqueous humor samples will be collected for Inflammatory factor testing and IOP control every 4 weeks.

Electroretinogram was performed every 4 weeks.