Project COMET: Massed Prolonged Exposure for PTSD and SUD

NANot yet recruitingINTERVENTIONAL
Enrollment

168

Participants

Timeline

Start Date

June 1, 2025

Primary Completion Date

June 30, 2029

Study Completion Date

June 30, 2029

Conditions
Posttraumatic Stress Disorder (PTSD)Substance Use Disorders (SUD)ComorbidityTrauma and Stressor Related Disorders
Interventions
BEHAVIORAL

Massed Prolonged Exposure Therapy (M-PE)

Massed Prolonged Exposure (M-PE) is a trauma-focused, evidence-based behavioral intervention for posttraumatic stress disorder (PTSD). It is delivered over a compressed timeline (e.g., 10 sessions over 2-4 weeks) as opposed to weekly sessions over 3-4 months. This format has been shown to accelerate PTSD symptom reduction and reduce treatment dropout. In this study, M-PE will be delivered concurrently with an Intensive Outpatient Program (IOP) for substance use disorder (SUD) at Gateway Community Services. Sessions will be led by trained clinicians using a standardized PE protocol, with treatment including imaginal exposure, in vivo exposure, and processing.

BEHAVIORAL

Standard outpatient SUD care

"Patients randomized to usual care will receive standard intensive outpatient SUD treatment.~* Resilience group (weekly)~* Peer support~* Individual therapy from a variety of modalities"

Trial Locations (1)

32204

Gateway Community Services, Jacksonville

All Listed Sponsors
collaborator

National Institute of Mental Health (NIMH)

NIH

collaborator

University of California, San Diego

OTHER

collaborator

University of Minnesota

OTHER

lead

Rutgers, The State University of New Jersey

OTHER

NCT06968832 - Project COMET: Massed Prolonged Exposure for PTSD and SUD | Biotech Hunter | Biotech Hunter