Effects of High-Intensity, Low-Frequency Periodic rTMS Over the Right Dorsolateral Prefrontal Cortex on Cardiac Autonomic Regulation in Women With Recurrent Pregnancy Loss and Anxiety: A Proof-of-Concept rTMS-ECG Clinical Trial ( NEURO-CARD)

NARecruitingINTERVENTIONAL
Enrollment

55

Participants

Timeline

Start Date

May 16, 2025

Primary Completion Date

March 13, 2026

Study Completion Date

March 30, 2026

Conditions
Recurrent Pregnancy LossAnxiety Disorders
Interventions
DEVICE

repetitive transcranial magnetic stimulation(rTMS)

The eligible participants will undergo an intensity sweep consisting of six stimulation trains over the right dorsolateral prefrontal cortex (DLPFC), with stimulation intensities ranging from 100% to 150% of the individual resting motor threshold (RMT), increasing in 10% increments. Each train will last 60 seconds, comprising 40 seconds of active rTMS at 1 Hz and a 20-second intertrain interval (ITI). Synchronous electrocardiogram (ECG) data will be continuously recorded throughout the entire procedure.

Trial Locations (3)

110001

RECRUITING

The Second Affiliated Hospital of Shenyang Medical College, Shenyang

China

RECRUITING

Shenyang Jinghua Hospital, Shenyang

Unknown

RECRUITING

Central Hospital Affiliated to Shenyang Medical Collage, Shenyang

All Listed Sponsors
collaborator

Central Hospital Affiliated to Shenyang Medical Collage

OTHER

collaborator

Shenyang Medical College

OTHER

collaborator

The Second Hospital of Shenyang Medical College

OTHER

collaborator

242 Hospital Affiliated to Shenyang Medical College

UNKNOWN

lead

Shenyang Jinghua Hospital

INDUSTRY