Selection and Efficacy-Influencing Factors of First-Line Biologic Agents in Moderate-to-Severe Ulcerative Colitis

RecruitingOBSERVATIONAL
Enrollment

400

Participants

Timeline

Start Date

April 30, 2025

Primary Completion Date

November 20, 2025

Study Completion Date

November 20, 2025

Conditions
Ulcerative Colitis (UC)
Interventions
DRUG

first-line biologic:IFX

IFX is administered intravenously at a dose of 5-10mg/kg, once at weeks 0, 2, and 6 (or 0, 1, and 5), and then every 8 weeks at a dose of 5mg/kg for maintenance treatment. VDZ is administered intravenously at a dose of 300mg/time, once at weeks 0, 2, and 6, and then every 8 weeks at a dose of 300mg for maintenance treatment.

DRUG

first-line biologic:VDZ

IFX is administered intravenously at a dose of 5-10mg/kg, once at weeks 0, 2, and 6 (or 0, 1, and 5), and then every 8 weeks at a dose of 5mg/kg for maintenance treatment. VDZ is administered intravenously at a dose of 300mg/time, once at weeks 0, 2, and 6, and then every 8 weeks at a dose of 300mg for maintenance treatment.

Trial Locations (1)

710032

RECRUITING

Xijing Hospital of Digestive Diseases, Shanxi

All Listed Sponsors
lead

Xijing Hospital of Digestive Diseases

OTHER