Mechanisms of Change in Behavioral Cough Suppression Therapy for Refractory Chronic Cough

PHASE2Not yet recruitingINTERVENTIONAL
Enrollment

150

Participants

Timeline

Start Date

August 1, 2025

Primary Completion Date

June 30, 2029

Study Completion Date

March 31, 2030

Conditions
Chronic Cough (CC)Refractory Chronic CoughUnexplained Chronic Cough
Interventions
BEHAVIORAL

Behavioral cough suppression therapy combined with inactive inhaled drug (BCS+Sham)

Behavioral cough suppression therapy plus inactive inhaled drug. Treatment given twice per week for 12 sessions.

COMBINATION_PRODUCT

Behavioral cough suppression therapy combined with capsaicin inhalation (BCS+CAP)

Behavioral cough suppression therapy combined with inhaled capsaicin (cough stimulant). Treatment given twice per week for 12 sessions.

DRUG

Inhaled capsaicin (CAP)

Repeated inhalation of diluted capsaicin in increasing concentrations. Treatment given twice per week for 12 sessions.

Trial Locations (3)

30322

Emory University, Atlanta

59812

University of Montana, Missoula

80045

University of Colorado Anschutz Medical Campus, Aurora

All Listed Sponsors
collaborator

University of Colorado, Denver

OTHER

collaborator

Emory University

OTHER

collaborator

University of Melbourne

OTHER

lead

University of Montana

OTHER