The Effect of Hyaluronic Acid Injection on TNF-Alpha and IL-1β in Knee Osteoarthritis

NARecruitingINTERVENTIONAL
Enrollment

50

Participants

Timeline

Start Date

May 12, 2025

Primary Completion Date

June 30, 2025

Study Completion Date

December 29, 2025

Conditions
Knee OsteoarthritisHyaluronic Acid
Interventions
DEVICE

Hyaluronic Acid injections

Intra-articular hyaluronic acid will be administered to 30 selected patients. Blood and synovial fluid samples will be collected before HA injection and 1 week after 3 sessions of HA injection with one week interval. Home exercise programme will be given.

OTHER

Saline -- placebo comparator

Intra-articular saline (SF) will be administered to 20 selected patients. Blood and synovial fluid samples will be collected before and 1 week after 3 session of salin injection with one week interval. Home exercise programme will be given.

Trial Locations (1)

Unknown

RECRUITING

Istanbul University, Istanbul Faculty of Medicine, Istanbul

All Listed Sponsors
collaborator

Istanbul University Research Fund

UNKNOWN

lead

Istanbul University

OTHER