Study to Evaluate the Efficacy and Safety of Ruxolitinib Cream in Participants With Hidradenitis Suppurativa (TRuE-HS1)

PHASE3RecruitingINTERVENTIONAL
Enrollment

400

Participants

Timeline

Start Date

June 23, 2025

Primary Completion Date

October 9, 2026

Study Completion Date

July 11, 2027

Conditions
Hidradenitis Suppurativa
Interventions
DRUG

Ruxolitinib Cream

Ruxolitinib cream applied topically to the affected area as a thin film twice daily.

DRUG

Vehicle Cream

Matching vehicle cream applied topically to the affected area as a thin film twice daily.

Trial Locations (108)

10003

RECRUITING

Investigative Site US018, New York

10023

RECRUITING

Investigative Site US017, New York

10117

RECRUITING

Investigative Site DE006, Berlin

10126

NOT_YET_RECRUITING

Investigative Site IT008, Torino

10956

RECRUITING

Investigative Site US034, New City

13595

NOT_YET_RECRUITING

Investigative Site DE005, Berlin

14623

RECRUITING

Investigative Site US023, Rochester

17822

NOT_YET_RECRUITING

Investigative Site US043, Danville

19107

NOT_YET_RECRUITING

Investigative Site US056, Philadelphia

20089

NOT_YET_RECRUITING

Investigative Site IT002, Rozzano

20122

NOT_YET_RECRUITING

Investigative Site IT003, Milan

20246

NOT_YET_RECRUITING

Investigative Site DE007, Hamburg

20769

RECRUITING

Investigative Site US046, Glenn Dale

23538

NOT_YET_RECRUITING

Investigative Site DE008, Lübeck

27516

NOT_YET_RECRUITING

Investigative Site US014, Chapel Hill

28009

NOT_YET_RECRUITING

Investigative Site ES001, Madrid

28040

NOT_YET_RECRUITING

Investigative Site ES002, Madrid

29425

RECRUITING

Investigative Site US024, Charleston

29609

RECRUITING

Investigative Site FR005, Brest

29788

RECRUITING

Investigative Site US041, Myrtle Beach

30060

RECRUITING

Investigative Site US019, Marietta

30322

NOT_YET_RECRUITING

Investigative Site US061, Atlanta

30331

NOT_YET_RECRUITING

Investigative Site US053, Atlanta

32771

RECRUITING

Investigative Site US027, Sanford

33000

NOT_YET_RECRUITING

Investigative Site FR002, Bordeaux

33142

RECRUITING

Investigative Site US016, Miami

33172

RECRUITING

Investigative Site US057, Sweetwater

33437

RECRUITING

Investigative Site US045, Boynton Beach

33609

RECRUITING

Investigative Site US029, Tampa

33912

RECRUITING

Investigative Site US028, Fort Myers

37130

NOT_YET_RECRUITING

Investigative Site US005, Murfreesboro

37215

RECRUITING

Investigative Site US047, Nashville

40241

RECRUITING

Investigative Site US022, Louisville

42104

RECRUITING

Investigative Site US001, Bowling Green

43209

RECRUITING

Investigative Site US015, Bexley

43230

RECRUITING

Investigative Site US008, Columbus

44093

RECRUITING

Investigative Site FR004, Nantes

44124

NOT_YET_RECRUITING

Investigative Site IT005, Cona

44791

NOT_YET_RECRUITING

Investigative Site DE002, Bochum

45040

RECRUITING

Investigative Site US031, Mason

45219

NOT_YET_RECRUITING

Investigative Site US044, Cincinnati

47129

RECRUITING

Investigative Site US049, Clarksville

47906

RECRUITING

Investigative Site US052, West Lafayette

48201

NOT_YET_RECRUITING

Investigative Site US051, Detroit

50122

NOT_YET_RECRUITING

Investigative Site IT009, Florence

55112

RECRUITING

Investigative Site US021, New Brighton

55455

NOT_YET_RECRUITING

Investigative Site US006, Minneapolis

58103

RECRUITING

Investigative Site US025, Fargo

60048

NOT_YET_RECRUITING

Investigative Site US042, Libertyville

60657

RECRUITING

Investigative Site US026, Chicago

64283

NOT_YET_RECRUITING

Investigative Site DE004, Darmstadt

64506

RECRUITING

Investigative Site US036, Saint Joseph

70809

RECRUITING

Investigative Site US050, Baton Rouge

72703

RECRUITING

Investigative Site US002, Fayetteville

73118

RECRUITING

Investigative Site US048, Oklahoma City

75010

NOT_YET_RECRUITING

Investigative Site FR001, Paris

75025

RECRUITING

Investigative Site US012, Plano

75033

RECRUITING

Investigative Site US032, Frisco

75390

NOT_YET_RECRUITING

Investigative Site US062, Dallas

78213

RECRUITING

Investigative Site US011, San Antonio

79902

RECRUITING

Investigative Site US035, El Paso

80045

NOT_YET_RECRUITING

Investigative Site US059, Aurora

80131

NOT_YET_RECRUITING

Investigative Site IT007, Naples

84041

RECRUITING

Investigative Site US040, Layton

84107

NOT_YET_RECRUITING

Investigative Site US037, Murray

84405

RECRUITING

Investigative Site US039, Ogden

85008

RECRUITING

Investigative Site US020, Phoenix

85259

NOT_YET_RECRUITING

Investigative Site US033, Scottsdale

85282

RECRUITING

Investigative Site US054, Tempe

90033

NOT_YET_RECRUITING

Investigative Site US007, Los Angeles

91054

NOT_YET_RECRUITING

Investigative Site DE003, Erlangen

92103

RECRUITING

Investigative Site US013, San Diego

92120

RECRUITING

Investigative Site US060, San Diego

92121

RECRUITING

Investigative Site US038, San Diego

92677

RECRUITING

Investigative Site US004, Laguna Niguel

92821

RECRUITING

Investigative Site US055, Brea

95123

NOT_YET_RECRUITING

Investigative Site IT001, Catania

98195

NOT_YET_RECRUITING

Investigative Site US058, Seattle

02115

NOT_YET_RECRUITING

Investigative Site US003, Boston

02169

RECRUITING

Investigative Site US010, Quincy

01407

RECRUITING

Investigative Site BG002, Sofia

01463

RECRUITING

Investigative Site BG003, Sofia

06000

NOT_YET_RECRUITING

Investigative Site BG001, Stara Zagora

T2J 7E1

RECRUITING

Investigative Site CA004, Calgary

T3E 0B2

NOT_YET_RECRUITING

Investigative Site CA003, Calgary

K1K 4L2

RECRUITING

Investigative Site CA009, Ottawa

K9J 5K2

RECRUITING

Investigative Site CA002, Peterborough

L4B 1L1

RECRUITING

Investigative Site CA001, Richmond Hill

M3B 0A7

RECRUITING

Investigative Site CA007, Toronto

M4E 1R7

RECRUITING

Investigative Site CA005, Toronto

N2J 1C4

RECRUITING

Investigative Site CA006, Waterloo

J1G 1X9

NOT_YET_RECRUITING

Investigative Site CA008, Sherbrooke

06200

NOT_YET_RECRUITING

Investigative Site FR003, Nice

01307

NOT_YET_RECRUITING

Investigative Site DE001, Dresden

00137

NOT_YET_RECRUITING

Investigative Site IT006, Roma

00144

NOT_YET_RECRUITING

Investigative Site IT004, Roma

90-436

RECRUITING

Investigative Site PL002, Lodz

87-100

NOT_YET_RECRUITING

Investigative Site PL003, Torun

02-962

NOT_YET_RECRUITING

Investigative Site PL001, Warsaw

54-239

NOT_YET_RECRUITING

Investigative Site PL004, Wroclaw

03010

RECRUITING

Investigative Site ES004, Alicante

08916

NOT_YET_RECRUITING

Investigative Site ES005, Badalona

08003

NOT_YET_RECRUITING

Investigative Site ES003, Barcelona

CF14 4XU

NOT_YET_RECRUITING

Investigative Site GB001, Cardiff

HG2 7SX

NOT_YET_RECRUITING

Investigative Site GB004, Harrogate

IP4 5PD

NOT_YET_RECRUITING

Investigative Site GB002, Ipswich

SE1 9RT

NOT_YET_RECRUITING

Investigative Site GB006, London

RH1 5RH

NOT_YET_RECRUITING

Investigative Site GB003, Redhill

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Incyte Corporation

INDUSTRY