356
Participants
Start Date
August 21, 2025
Primary Completion Date
October 21, 2030
Study Completion Date
October 21, 2030
Biopsy Procedure
Undergo tumor tissue biopsy
Biospecimen Collection
Undergo blood sample collection
Capecitabine
Given capecitabine
Computed Tomography
Undergo CT
Dose-escalated Radiation Therapy
Undergo dose-escalated radiation using intensity-modulated radiation therapy treatment planning
Fluorouracil
Given fluorouracil
Gemcitabine
Given gemcitabine
Irinotecan Hydrochloride
Given irinotecan hydrochloride
Irinotecan Sucrosofate
Given liposomal irinotecan
Leucovorin Calcium
Given leucovorin calcium
Magnetic Resonance Imaging
Undergo MRI
Nab-paclitaxel
Given nab-paclitaxel
Observation Activity
Undergo observation
Oxaliplatin
Given oxaliplatin
Questionnaire Administration
Ancillary studies
Radiation Therapy
Undergo standard radiation therapy
RECRUITING
Jefferson Hospital, Jefferson Hills
RECRUITING
Forbes Hospital, Monroeville
RECRUITING
Allegheny General Hospital, Pittsburgh
RECRUITING
West Penn Hospital, Pittsburgh
RECRUITING
Reading Hospital, West Reading
RECRUITING
Inova Loudoun Hospital, Leesburg
RECRUITING
William E Kahlert Regional Cancer Center/Sinai Hospital, Westminster
RECRUITING
Sinai Hospital of Baltimore, Baltimore
RECRUITING
Inova Schar Cancer Institute, Fairfax
RECRUITING
Inova Fair Oaks Hospital, Fairfax
RECRUITING
Inova Fairfax Hospital, Falls Church
RECRUITING
Inova Alexandria Hospital, Alexandria
RECRUITING
Bon Secours Saint Francis Medical Center, Midlothian
RECRUITING
Bon Secours Saint Mary's Hospital, Richmond
RECRUITING
Bon Secours Cancer Institute at Reynolds Crossing, Richmond
RECRUITING
UNC Lineberger Comprehensive Cancer Center, Chapel Hill
RECRUITING
Memorial Health University Medical Center, Savannah
RECRUITING
University of Florida Health Science Center - Gainesville, Gainesville
RECRUITING
Baptist Memorial Hospital and Cancer Center-Collierville, Collierville
RECRUITING
Baptist Memorial Hospital and Cancer Center-Memphis, Memphis
RECRUITING
Baptist Memorial Hospital and Cancer Center-Union County, New Albany
RECRUITING
Baptist Memorial Hospital and Cancer Center-Oxford, Oxford
RECRUITING
Baptist Memorial Hospital and Cancer Center-Desoto, Southhaven
RECRUITING
Baptist Cancer Center-Grenada, Grenada
RECRUITING
Baptist Memorial Hospital and Cancer Center-Golden Triangle, Columbus
RECRUITING
University of Kentucky/Markey Cancer Center, Lexington
RECRUITING
ProMedica Flower Hospital, Sylvania
RECRUITING
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital, Toledo
RECRUITING
University of Cincinnati Cancer Center-West Chester, West Chester
RECRUITING
University of Cincinnati Cancer Center-UC Medical Center, Cincinnati
RECRUITING
Goshen Center for Cancer Care, Goshen
RECRUITING
Henry Ford Macomb Hospital-Clinton Township, Clinton Township
RECRUITING
Henry Ford Medical Center-Fairlane, Dearborn
RECRUITING
Henry Ford Hospital, Detroit
RECRUITING
Henry Ford West Bloomfield Hospital, West Bloomfield
RECRUITING
Henry Ford Medical Center-Columbus, Novi
RECRUITING
Allegiance Health, Jackson
RECRUITING
UI Health Care Mission Cancer and Blood - Ankeny Clinic, Ankeny
RECRUITING
UI Health Care Mission Cancer and Blood - Waukee Clinic, Waukee
RECRUITING
Iowa Methodist Medical Center, Des Moines
RECRUITING
UI Health Care Mission Cancer and Blood - Des Moines Clinic, Des Moines
RECRUITING
UI Health Care Mission Cancer and Blood - Laurel Clinic, Des Moines
RECRUITING
UI Health Care Mission Cancer and Blood - West Des Moines Clinic, Clive
RECRUITING
Aspirus Regional Cancer Center, Wausau
RECRUITING
Langlade Hospital and Cancer Center, Antigo
RECRUITING
Aspirus Cancer Care - Stevens Point, Stevens Point
RECRUITING
Aspirus Cancer Care - Wisconsin Rapids, Wisconsin Rapids
RECRUITING
Aspirus Cancer Care - James Beck Cancer Center, Rhinelander
RECRUITING
Rush-Copley Medical Center, Aurora
RECRUITING
Carle Cancer Center, Urbana
RECRUITING
Carle at The Riverfront, Danville
RECRUITING
Carle Physician Group-Mattoon/Charleston, Mattoon
RECRUITING
Cancer Care Center of O'Fallon, O'Fallon
RECRUITING
HSHS Saint Elizabeth's Hospital, O'Fallon
RECRUITING
Carle Physician Group-Effingham, Effingham
RECRUITING
Crossroads Cancer Center, Effingham
RECRUITING
Cancer Care Specialists of Illinois - Decatur, Decatur
RECRUITING
Decatur Memorial Hospital, Decatur
RECRUITING
Southern Illinois University School of Medicine, Springfield
RECRUITING
Springfield Clinic, Springfield
RECRUITING
Springfield Memorial Hospital, Springfield
RECRUITING
Centralia Oncology Clinic, Centralia
RECRUITING
University of Kansas Cancer Center - Lee's Summit, Lee's Summit
RECRUITING
University of Kansas Cancer Center - North, Kansas City
RECRUITING
The University of Kansas Cancer Center - Olathe, Olathe
RECRUITING
University of Kansas Cancer Center, Kansas City
RECRUITING
University of Kansas Hospital-Westwood Cancer Center, Westwood
RECRUITING
University of Kansas Cancer Center-Overland Park, Overland Park
RECRUITING
University of Kansas Health System Saint Francis Campus, Topeka
RECRUITING
University of Nebraska Medical Center, Omaha
RECRUITING
NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro, Jonesboro
RECRUITING
Houston Methodist Hospital, Houston
RECRUITING
University of Texas Health Science Center at San Antonio, San Antonio
RECRUITING
Rocky Mountain Cancer Centers-Boulder, Boulder
RECRUITING
Arizona Center for Cancer Care - Phoenix, Phoenix
RECRUITING
Arizona Center for Cancer Care - Scottsdale, Scottsdale
RECRUITING
Arizona Center for Cancer Care, Tempe
RECRUITING
Arizona Center for Cancer Care - Gilbert, Gilbert
RECRUITING
Arizona Center for Cancer Care-Surprise, Surprise
RECRUITING
Arizona Center for Cancer Care-Peoria, Peoria
RECRUITING
Renown Regional Medical Center, Reno
RECRUITING
Ridley-Tree Cancer Center, Santa Barbara
RECRUITING
AIS Cancer Center at San Joaquin Community Hospital, Bakersfield
RECRUITING
Palo Alto Medical Foundation-Camino Division, Mountain View
RECRUITING
Palo Alto Medical Foundation-Sunnyvale, Sunnyvale
RECRUITING
Palo Alto Medical Foundation Health Care, Palo Alto
RECRUITING
Palo Alto Medical Foundation-Fremont, Fremont
RECRUITING
Sutter Solano Medical Center/Cancer Center, Vallejo
RECRUITING
BASS Medical Group - Lennon, Walnut Creek
RECRUITING
Alta Bates Summit Medical Center-Herrick Campus, Berkeley
RECRUITING
Memorial Medical Center, Modesto
RECRUITING
Sutter Pacific Medical Foundation, Santa Rosa
RECRUITING
Sutter Cancer Centers Radiation Oncology Services-Roseville, Roseville
RECRUITING
Sutter Roseville Medical Center, Roseville
RECRUITING
Sutter Cancer Centers Radiation Oncology Services-Cameron Park, Cameron Park
RECRUITING
Sutter Medical Center Sacramento, Sacramento
RECRUITING
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon
RECRUITING
Dartmouth Cancer Center - North, Saint Johnsbury
Lead Sponsor
NRG Oncology
OTHER