Testing Higher Dose Radiation Therapy for Locally Advanced Pancreatic Cancer

PHASE3RecruitingINTERVENTIONAL
Enrollment

356

Participants

Timeline

Start Date

August 21, 2025

Primary Completion Date

October 21, 2030

Study Completion Date

October 21, 2030

Conditions
Locally Advanced Unresectable Pancreatic Ductal AdenocarcinomaStage II Pancreatic Cancer AJCC v8Stage III Pancreatic Cancer AJCC v8Stage IV Pancreatic Cancer AJCC v8
Interventions
PROCEDURE

Biopsy Procedure

Undergo tumor tissue biopsy

PROCEDURE

Biospecimen Collection

Undergo blood sample collection

DRUG

Capecitabine

Given capecitabine

PROCEDURE

Computed Tomography

Undergo CT

RADIATION

Dose-escalated Radiation Therapy

Undergo dose-escalated radiation using intensity-modulated radiation therapy treatment planning

DRUG

Fluorouracil

Given fluorouracil

DRUG

Gemcitabine

Given gemcitabine

DRUG

Irinotecan Hydrochloride

Given irinotecan hydrochloride

DRUG

Irinotecan Sucrosofate

Given liposomal irinotecan

DRUG

Leucovorin Calcium

Given leucovorin calcium

PROCEDURE

Magnetic Resonance Imaging

Undergo MRI

DRUG

Nab-paclitaxel

Given nab-paclitaxel

OTHER

Observation Activity

Undergo observation

DRUG

Oxaliplatin

Given oxaliplatin

OTHER

Questionnaire Administration

Ancillary studies

RADIATION

Radiation Therapy

Undergo standard radiation therapy

Trial Locations (98)

15025

RECRUITING

Jefferson Hospital, Jefferson Hills

15146

RECRUITING

Forbes Hospital, Monroeville

15212

RECRUITING

Allegheny General Hospital, Pittsburgh

15224

RECRUITING

West Penn Hospital, Pittsburgh

19611

RECRUITING

Reading Hospital, West Reading

20176

RECRUITING

Inova Loudoun Hospital, Leesburg

21157

RECRUITING

William E Kahlert Regional Cancer Center/Sinai Hospital, Westminster

21215

RECRUITING

Sinai Hospital of Baltimore, Baltimore

22031

RECRUITING

Inova Schar Cancer Institute, Fairfax

22033

RECRUITING

Inova Fair Oaks Hospital, Fairfax

22042

RECRUITING

Inova Fairfax Hospital, Falls Church

22304

RECRUITING

Inova Alexandria Hospital, Alexandria

23114

RECRUITING

Bon Secours Saint Francis Medical Center, Midlothian

23226

RECRUITING

Bon Secours Saint Mary's Hospital, Richmond

23230

RECRUITING

Bon Secours Cancer Institute at Reynolds Crossing, Richmond

27599

RECRUITING

UNC Lineberger Comprehensive Cancer Center, Chapel Hill

31404

RECRUITING

Memorial Health University Medical Center, Savannah

32610

RECRUITING

University of Florida Health Science Center - Gainesville, Gainesville

38017

RECRUITING

Baptist Memorial Hospital and Cancer Center-Collierville, Collierville

38120

RECRUITING

Baptist Memorial Hospital and Cancer Center-Memphis, Memphis

38652

RECRUITING

Baptist Memorial Hospital and Cancer Center-Union County, New Albany

38655

RECRUITING

Baptist Memorial Hospital and Cancer Center-Oxford, Oxford

38671

RECRUITING

Baptist Memorial Hospital and Cancer Center-Desoto, Southhaven

38901

RECRUITING

Baptist Cancer Center-Grenada, Grenada

39705

RECRUITING

Baptist Memorial Hospital and Cancer Center-Golden Triangle, Columbus

40536

RECRUITING

University of Kentucky/Markey Cancer Center, Lexington

43560

RECRUITING

ProMedica Flower Hospital, Sylvania

43606

RECRUITING

ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital, Toledo

45069

RECRUITING

University of Cincinnati Cancer Center-West Chester, West Chester

45219

RECRUITING

University of Cincinnati Cancer Center-UC Medical Center, Cincinnati

46526

RECRUITING

Goshen Center for Cancer Care, Goshen

48038

RECRUITING

Henry Ford Macomb Hospital-Clinton Township, Clinton Township

48126

RECRUITING

Henry Ford Medical Center-Fairlane, Dearborn

48202

RECRUITING

Henry Ford Hospital, Detroit

48322

RECRUITING

Henry Ford West Bloomfield Hospital, West Bloomfield

48377

RECRUITING

Henry Ford Medical Center-Columbus, Novi

49201

RECRUITING

Allegiance Health, Jackson

50023

RECRUITING

UI Health Care Mission Cancer and Blood - Ankeny Clinic, Ankeny

50263

RECRUITING

UI Health Care Mission Cancer and Blood - Waukee Clinic, Waukee

50309

RECRUITING

Iowa Methodist Medical Center, Des Moines

RECRUITING

UI Health Care Mission Cancer and Blood - Des Moines Clinic, Des Moines

50314

RECRUITING

UI Health Care Mission Cancer and Blood - Laurel Clinic, Des Moines

50325

RECRUITING

UI Health Care Mission Cancer and Blood - West Des Moines Clinic, Clive

54401

RECRUITING

Aspirus Regional Cancer Center, Wausau

54409

RECRUITING

Langlade Hospital and Cancer Center, Antigo

54481

RECRUITING

Aspirus Cancer Care - Stevens Point, Stevens Point

54494

RECRUITING

Aspirus Cancer Care - Wisconsin Rapids, Wisconsin Rapids

54501

RECRUITING

Aspirus Cancer Care - James Beck Cancer Center, Rhinelander

60504

RECRUITING

Rush-Copley Medical Center, Aurora

61801

RECRUITING

Carle Cancer Center, Urbana

61832

RECRUITING

Carle at The Riverfront, Danville

61938

RECRUITING

Carle Physician Group-Mattoon/Charleston, Mattoon

62269

RECRUITING

Cancer Care Center of O'Fallon, O'Fallon

RECRUITING

HSHS Saint Elizabeth's Hospital, O'Fallon

62401

RECRUITING

Carle Physician Group-Effingham, Effingham

RECRUITING

Crossroads Cancer Center, Effingham

62526

RECRUITING

Cancer Care Specialists of Illinois - Decatur, Decatur

RECRUITING

Decatur Memorial Hospital, Decatur

62702

RECRUITING

Southern Illinois University School of Medicine, Springfield

RECRUITING

Springfield Clinic, Springfield

62781

RECRUITING

Springfield Memorial Hospital, Springfield

62801

RECRUITING

Centralia Oncology Clinic, Centralia

64064

RECRUITING

University of Kansas Cancer Center - Lee's Summit, Lee's Summit

64154

RECRUITING

University of Kansas Cancer Center - North, Kansas City

66061

RECRUITING

The University of Kansas Cancer Center - Olathe, Olathe

66160

RECRUITING

University of Kansas Cancer Center, Kansas City

66205

RECRUITING

University of Kansas Hospital-Westwood Cancer Center, Westwood

66210

RECRUITING

University of Kansas Cancer Center-Overland Park, Overland Park

66606

RECRUITING

University of Kansas Health System Saint Francis Campus, Topeka

68198

RECRUITING

University of Nebraska Medical Center, Omaha

72401

RECRUITING

NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro, Jonesboro

77030

RECRUITING

Houston Methodist Hospital, Houston

78229

RECRUITING

University of Texas Health Science Center at San Antonio, San Antonio

80304

RECRUITING

Rocky Mountain Cancer Centers-Boulder, Boulder

85027

RECRUITING

Arizona Center for Cancer Care - Phoenix, Phoenix

85258

RECRUITING

Arizona Center for Cancer Care - Scottsdale, Scottsdale

85284

RECRUITING

Arizona Center for Cancer Care, Tempe

85297

RECRUITING

Arizona Center for Cancer Care - Gilbert, Gilbert

85374

RECRUITING

Arizona Center for Cancer Care-Surprise, Surprise

85381

RECRUITING

Arizona Center for Cancer Care-Peoria, Peoria

89502

RECRUITING

Renown Regional Medical Center, Reno

93105

RECRUITING

Ridley-Tree Cancer Center, Santa Barbara

93301

RECRUITING

AIS Cancer Center at San Joaquin Community Hospital, Bakersfield

94040

RECRUITING

Palo Alto Medical Foundation-Camino Division, Mountain View

94086

RECRUITING

Palo Alto Medical Foundation-Sunnyvale, Sunnyvale

94301

RECRUITING

Palo Alto Medical Foundation Health Care, Palo Alto

94538

RECRUITING

Palo Alto Medical Foundation-Fremont, Fremont

94589

RECRUITING

Sutter Solano Medical Center/Cancer Center, Vallejo

94598

RECRUITING

BASS Medical Group - Lennon, Walnut Creek

94704

RECRUITING

Alta Bates Summit Medical Center-Herrick Campus, Berkeley

95355

RECRUITING

Memorial Medical Center, Modesto

95403

RECRUITING

Sutter Pacific Medical Foundation, Santa Rosa

95661

RECRUITING

Sutter Cancer Centers Radiation Oncology Services-Roseville, Roseville

RECRUITING

Sutter Roseville Medical Center, Roseville

95682

RECRUITING

Sutter Cancer Centers Radiation Oncology Services-Cameron Park, Cameron Park

95816

RECRUITING

Sutter Medical Center Sacramento, Sacramento

03756

RECRUITING

Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon

05819

RECRUITING

Dartmouth Cancer Center - North, Saint Johnsbury

Sponsors

Lead Sponsor

All Listed Sponsors
lead

NRG Oncology

OTHER

NCT06958328 - Testing Higher Dose Radiation Therapy for Locally Advanced Pancreatic Cancer | Biotech Hunter | Biotech Hunter