Study to Evaluate the Efficacy and Safety of Ruxolitinib Cream in Participants With Hidradenitis Suppurativa (TRuE-HS2)

PHASE3RecruitingINTERVENTIONAL
Enrollment

450

Participants

Timeline

Start Date

June 12, 2025

Primary Completion Date

October 9, 2026

Study Completion Date

July 11, 2027

Conditions
Hidradenitis Suppurativa
Interventions
DRUG

Ruxolitinib Cream

Ruxolitinib cream applied topically to the affected area as a thin film twice daily.

DRUG

Vehicle Cream

Matching vehicle cream applied topically to the affected area as a thin film twice daily.

Trial Locations (111)

10003

NOT_YET_RECRUITING

Investigative Site US246, New York

10075

RECRUITING

Investigative Site US242, New York

11203

NOT_YET_RECRUITING

Investigative Site US219, Brooklyn

11415

RECRUITING

Investigative Site US213, Kew Gardens

14450

NOT_YET_RECRUITING

Investigative Site US269, Fairport

14620

NOT_YET_RECRUITING

Investigative Site US245, Rochester

15706

NOT_YET_RECRUITING

Investigative Site ES204, Santiago de Compostela

18014

NOT_YET_RECRUITING

Investigative Site ES201, Granada

19462

RECRUITING

Investigative Site US226, Plymouth Meeting

21054

NOT_YET_RECRUITING

Investigative Site US254, Gambrills

21104

RECRUITING

Investigative Site US201, Marriottsville

22206

RECRUITING

Investigative Site US248, Arlington

23502

RECRUITING

Investigative Site US229, Norfolk

24105

NOT_YET_RECRUITING

Investigative Site DE203, Kiel

24541

RECRUITING

Investigative Site US209, Danville

27104

NOT_YET_RECRUITING

Investigative Site US263, Winston-Salem

28041

NOT_YET_RECRUITING

Investigative Site ES203, Madrid

28078

RECRUITING

Investigative Site US259, Huntersville

29464

RECRUITING

Investigative Site US267, Mt. Pleasant

29910

RECRUITING

Investigative Site US256, Bluffton

30159

RECRUITING

Investigative Site DE202, Hanover

30328

RECRUITING

Investigative Site US225, Sandy Springs

31059

NOT_YET_RECRUITING

Investigative Site FR202, Toulouse

31904

RECRUITING

Investigative Site US231, Columbus

32216

RECRUITING

Investigative Site US258, Jacksonville

32751

RECRUITING

Investigative Site US206, Maitland

33136

RECRUITING

Investigative Site US223, Miami

33147

RECRUITING

Investigative Site US241, Miami

33173

RECRUITING

Investigative Site US202, Miami

33486

RECRUITING

Investigative Site US208, Boca Raton

33609

RECRUITING

Investigative Site US214, Tampa

33612

NOT_YET_RECRUITING

Investigative Site US247, Tampa

35010

NOT_YET_RECRUITING

Investigative Site ES202, Las Palmas de Gran Canaria

35203

RECRUITING

Investigative Site US257, Birmingham

35244

RECRUITING

Investigative Site US218, Birmingham

36117

RECRUITING

Investigative Site US239, Montgomery

37075

NOT_YET_RECRUITING

Investigative Site DE206, Göttingen

42055

NOT_YET_RECRUITING

Investigative Site FR204, Saint-Etienne

43213

RECRUITING

Investigative Site US243, Columbus

RECRUITING

Investigative Site US249, Columbus

44124

RECRUITING

Investigative Site US228, Cleveland

46168

RECRUITING

Investigative Site US205, Plainfield

46940

NOT_YET_RECRUITING

Investigative Site ES207, Manises

48103

RECRUITING

Investigative Site US238, Ann Arbor

48326

RECRUITING

Investigative Site US230, Auburn Hills

48455

NOT_YET_RECRUITING

Investigative Site DE207, Bad Bentheim

51100

NOT_YET_RECRUITING

Investigative Site FR201, Reims

53226

NOT_YET_RECRUITING

Investigative Site US210, Milwaukee

59804

RECRUITING

Investigative Site US212, Missoula

60077

RECRUITING

Investigative Site US207, Skokie

63040

RECRUITING

Investigative Site US271, Wildwood

66663

NOT_YET_RECRUITING

Investigative Site DE204, Merzig

70012

NOT_YET_RECRUITING

Investigative Site US236, New Orleans

70112

NOT_YET_RECRUITING

Investigative Site US326, New Orleans

70115

RECRUITING

Investigative Site US266, New Orleans

70601

RECRUITING

Investigative Site US264, Lake Charles

75078

RECRUITING

Investigative Site US270, Prosper

76031

NOT_YET_RECRUITING

Investigative Site FR203, Rouen

77429

RECRUITING

Investigative Site US260, Cypress

77479

RECRUITING

Investigative Site US232, Sugar Land

78759

RECRUITING

Investigative Site US255, Austin

80109

RECRUITING

Investigative Site US244, Castle Rock

83340

WITHDRAWN

Investigative Site US233, Ketchum

85006

RECRUITING

Investigative Site US215, Phoenix

85037

RECRUITING

Investigative Site US261, Phoenix

85255

WITHDRAWN

Investigative Site US221, Scottsdale

85718

NOT_YET_RECRUITING

Investigative Site US240, Tucson

87102

NOT_YET_RECRUITING

Investigative Site US217, Albuquerque

89129

NOT_YET_RECRUITING

Investigative Site DE205, Langenau

89145

RECRUITING

Investigative Site US216, Las Vegas

90045

RECRUITING

Investigative Site US211, Los Angeles

90056

RECRUITING

Investigative Site US237, Los Angeles

91325

RECRUITING

Investigative Site US234, Northridge

91436

RECRUITING

Investigative Site US262, Encino

92706

RECRUITING

Investigative Site US250, Santa Ana

92708

RECRUITING

Investigative Site US222, Fountain Valley

97201

RECRUITING

Investigative Site US204, Portland

98105

NOT_YET_RECRUITING

Investigative Site US265, Seattle

99202

RECRUITING

Investigative Site US224, Spokane

06416

RECRUITING

Investigative Site US252, Cromwell

33012-3618

RECRUITING

Investigative Site US203, Hialeah

01757

RECRUITING

Investigative Site US253, Milford

02492

RECRUITING

Investigative Site US227, Needham

01605

NOT_YET_RECRUITING

Investigative Site US268, Worcester

63110-1010

RECRUITING

Investigative Site US251, St Louis

07030

RECRUITING

Investigative Site US235, Hoboken

01070

NOT_YET_RECRUITING

Investigative Site BE204, Brussels

09000

NOT_YET_RECRUITING

Investigative Site BE201, Ghent

NOT_YET_RECRUITING

Investigative Site BE203, Ghent

03000

NOT_YET_RECRUITING

Investigative Site BE202, Leuven

05400

RECRUITING

Investigative Site BG201, Sevlievo

01431

RECRUITING

Investigative Site BG202, Sofia

01592

RECRUITING

Investigative Site BG203, Sofia

T5K1X3

NOT_YET_RECRUITING

Investigative Site CA209, Edmonton

R3M 3Z4

RECRUITING

Investigative Site CA201, Winnipeg

E3B 1G9

RECRUITING

Investigative Site CA207, Fredericton

L8L 3C3

RECRUITING

Investigative Site CA202, Hamilton

N6H 5L5

RECRUITING

Investigative Site CA203, London

L3P 1X3

RECRUITING

Investigative Site CA204, Markham

L4W 0C2

RECRUITING

Investigative Site CA205, Mississauga

S7K 0H6

RECRUITING

Investigative Site CA208, Saskatoon

A1E 1V4

NOT_YET_RECRUITING

Investigative Site CA206, St. John's

1081GN

NOT_YET_RECRUITING

Investigative Site NL203, Amsterdam

3015 CE

NOT_YET_RECRUITING

Investigative Site NL201, Rotterdam

20-607

NOT_YET_RECRUITING

Investigative Site PL202, Lublin

60-309

RECRUITING

Investigative Site LP204, Poznan

35-055

NOT_YET_RECRUITING

Investigative Site PL201, Rzeszów

54-144

RECRUITING

Investigative Site PL203, Wroclaw

08041

NOT_YET_RECRUITING

Investigative Site ES205, Barcelona

08950

NOT_YET_RECRUITING

Investigative Site ES208, Esplugues de Llobregat

08402

NOT_YET_RECRUITING

Investigative Site ES206, Granollers

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Incyte Corporation

INDUSTRY