A Study of Metastases Free Survival With Saruparib vs Placebo Added to a Standard RT/ADT in Men With High-risk Prostate Cancer With a BRCA Mutation

PHASE3RecruitingINTERVENTIONAL
Enrollment

700

Participants

Timeline

Start Date

August 6, 2025

Primary Completion Date

April 22, 2033

Study Completion Date

May 22, 2036

Conditions
Prostate Cancer
Interventions
DRUG

Saruparib

Saruparib will be administered orally.

DRUG

Placebo

Matching placebo to saruparib will be administered orally.

DRUG

Abiraterone + Prednisolone/Prednisone

Abiraterone will be administered orally in combination with prednisone/prednisolone.

DRUG

Androgen Deprivation Therapy (ADT)

Standard of care ADT will be administered.

Trial Locations (195)

333

NOT_YET_RECRUITING

Research Site, Taoyuan District

704

NOT_YET_RECRUITING

Research Site, Tainan City

1020

NOT_YET_RECRUITING

Research Site, Vienna

1090

NOT_YET_RECRUITING

Research Site, Vienna

1122

NOT_YET_RECRUITING

Research Site, Budapest

1200

NOT_YET_RECRUITING

Research Site, Brussels

1307

NOT_YET_RECRUITING

Research Site, Dresden

2065

NOT_YET_RECRUITING

Research Site, St Leonards

2610

NOT_YET_RECRUITING

Research Site, Wilrijk

2747

NOT_YET_RECRUITING

Research Site, Kingswood

3722

NOT_YET_RECRUITING

Research Site, Seoul

4020

NOT_YET_RECRUITING

Research Site, Linz

4032

NOT_YET_RECRUITING

Research Site, Debrecen

5505

NOT_YET_RECRUITING

Research Site, Seoul

5700

NOT_YET_RECRUITING

Research Site, Gyula

6020

NOT_YET_RECRUITING

Research Site, Innsbruck

8035

NOT_YET_RECRUITING

Research Site, Barcelona

8036

NOT_YET_RECRUITING

Research Site, Graz

8500

NOT_YET_RECRUITING

Research Site, Kortrijk

8800

NOT_YET_RECRUITING

Research Site, Roeselare

10400

NOT_YET_RECRUITING

Research Site, Bangkok

10408

NOT_YET_RECRUITING

Research Site, Goyang-si

10450

WITHDRAWN

Research Site, Pulau Pinang

10700

NOT_YET_RECRUITING

Research Site, Bangkok

12120

NOT_YET_RECRUITING

Research Site, Pathum Thani

13008

NOT_YET_RECRUITING

Research Site, Trujillo

13273

NOT_YET_RECRUITING

Research Site, Marseille

15036

NOT_YET_RECRUITING

Research Site, Lima

15212

NOT_YET_RECRUITING

Research Site, Pittsburgh

16132

NOT_YET_RECRUITING

Research Site, Genoa

17007

NOT_YET_RECRUITING

Research Site, Girona

17033

NOT_YET_RECRUITING

Research Site, Hershey

20032

NOT_YET_RECRUITING

Research Site, Shanghai

20089

NOT_YET_RECRUITING

Research Site, Rozzano

20132

NOT_YET_RECRUITING

Research Site, Milan

20133

NOT_YET_RECRUITING

Research Site, Milan

20141

NOT_YET_RECRUITING

Research Site, Milan

20246

NOT_YET_RECRUITING

Research Site, Hamburg

20817

NOT_YET_RECRUITING

Research Site, Bethesda

21204

NOT_YET_RECRUITING

Research Site, Towson

23462

NOT_YET_RECRUITING

Research Site, Virginia Beach

23502

NOT_YET_RECRUITING

Research Site, Norfolk

24014

NOT_YET_RECRUITING

Research Site, Roanoke

27310

NOT_YET_RECRUITING

Research Site, Şahinbey

28040

NOT_YET_RECRUITING

Research Site, Madrid

28041

NOT_YET_RECRUITING

Research Site, Madrid

28046

NOT_YET_RECRUITING

Research Site, Madrid

29009

NOT_YET_RECRUITING

Research Site, Málaga

29010

NOT_YET_RECRUITING

Research Site, Málaga

29572

RECRUITING

Research Site, Myrtle Beach

30029

NOT_YET_RECRUITING

Research Site, Nîmes

30265

SUSPENDED

Research Site, Newnan

33000

NOT_YET_RECRUITING

Research Site, Bordeaux

33011

NOT_YET_RECRUITING

Research Site, Oviedo

33016

NOT_YET_RECRUITING

Research Site, Hialeah

33612

NOT_YET_RECRUITING

Research Site, Tampa

34010

NOT_YET_RECRUITING

Research Site, Istanbul

34070

NOT_YET_RECRUITING

Research Site, Montpellier

34098

NOT_YET_RECRUITING

Research Site, Istanbul

35040

NOT_YET_RECRUITING

Research Site, Izmir

35043

NOT_YET_RECRUITING

Research Site, Marburg

35392

NOT_YET_RECRUITING

Research Site, Giessen

35575

NOT_YET_RECRUITING

Research Site, Karşıyaka

37044

NOT_YET_RECRUITING

Research Site, Tours

37075

NOT_YET_RECRUITING

Research Site, Göttingen

37134

NOT_YET_RECRUITING

Research Site, Verona

37209

RECRUITING

Research Site, Nashville

38126

NOT_YET_RECRUITING

Research Site, Braunschweig

39008

NOT_YET_RECRUITING

Research Site, Santander

40002

NOT_YET_RECRUITING

Research Site, Khon Kaen

41404

NOT_YET_RECRUITING

Research Site, Daegu

42270

NOT_YET_RECRUITING

Research Site, Saint-Priest-en-Jarez

44625

NOT_YET_RECRUITING

Research Site, Herne

44805

NOT_YET_RECRUITING

Research Site, Saint-Herblain

45147

NOT_YET_RECRUITING

Research Site, Essen

46009

NOT_YET_RECRUITING

Research Site, Valencia

46014

NOT_YET_RECRUITING

Research Site, Valencia

47130

NOT_YET_RECRUITING

Research Site, Jeffersonville

47169

NOT_YET_RECRUITING

Research Site, Duisburg

49100

NOT_YET_RECRUITING

Research Site, Angers

49241

NOT_YET_RECRUITING

Research Site, Busan

50200

NOT_YET_RECRUITING

Research Site, Muang

50937

NOT_YET_RECRUITING

Research Site, Cologne

54511

NOT_YET_RECRUITING

Research Site, Vandœuvre-lès-Nancy

56126

NOT_YET_RECRUITING

Research Site, Pisa

59100

WITHDRAWN

Research Site, Kuala Lumpur

62250

WITHDRAWN

Research Site, Kuala Selangor

63011

NOT_YET_RECRUITING

Research Site, Clermont-Ferrand

67200

NOT_YET_RECRUITING

Research Site, Strasbourg

68100

WITHDRAWN

Research Site, Batu Caves

69310

NOT_YET_RECRUITING

Research Site, Pierre-Bénite

70124

NOT_YET_RECRUITING

Research Site, Bari

72000

NOT_YET_RECRUITING

Research Site, Le Mans

72622

NOT_YET_RECRUITING

Research Site, Nürtingen

75020

NOT_YET_RECRUITING

Research Site, Paris

75970

NOT_YET_RECRUITING

Research Site, Paris

77074

RECRUITING

Research Site, Houston

77380

NOT_YET_RECRUITING

Research Site, Spring

78229

RECRUITING

Research Site, San Antonio

78745

NOT_YET_RECRUITING

Research Site, Austin

80131

NOT_YET_RECRUITING

Research Site, Napoli

80215

NOT_YET_RECRUITING

Research Site, Lakewood

83301

NOT_YET_RECRUITING

Research Site, Kaohsiung City

84112

NOT_YET_RECRUITING

Research Site, Salt Lake City

85054

NOT_YET_RECRUITING

Research Site, Phoenix

85741

NOT_YET_RECRUITING

Research Site, Tucson

86156

NOT_YET_RECRUITING

Research Site, Augsburg

89081

NOT_YET_RECRUITING

Research Site, Ulm

90110

NOT_YET_RECRUITING

Research Site, Songkhla

90127

NOT_YET_RECRUITING

Research Site, Palermo

90419

NOT_YET_RECRUITING

Research Site, Nuremberg

92037

NOT_YET_RECRUITING

Research Site, La Jolla

92093

NOT_YET_RECRUITING

Research Site, La Jolla

92123

NOT_YET_RECRUITING

Research Site, San Diego

92151

NOT_YET_RECRUITING

Research Site, Suresnes

93053

NOT_YET_RECRUITING

Research Site, Regensburg

93401

NOT_YET_RECRUITING

Research Site, San Luis Obispo

94805

NOT_YET_RECRUITING

Research Site, Villejuif

97080

NOT_YET_RECRUITING

Research Site, Würzburg

97477

NOT_YET_RECRUITING

Research Site, Springfield

98109

NOT_YET_RECRUITING

Research Site, Seattle

100021

NOT_YET_RECRUITING

Research Site, Beijing

110042

NOT_YET_RECRUITING

Research Site, Shenyang

110085

WITHDRAWN

Research Site, Delhi

310022

NOT_YET_RECRUITING

Research Site, Hangzhou

315010

NOT_YET_RECRUITING

Research Site, Ningbo

330006

NOT_YET_RECRUITING

Research Site, Nanchang

361003

NOT_YET_RECRUITING

Research Site, Xiamen

400012

NOT_YET_RECRUITING

Research Site, Mumbai

440001

NOT_YET_RECRUITING

Research Site, Nagpur

610041

NOT_YET_RECRUITING

Research Site, Sichuan

629018

NOT_YET_RECRUITING

Research Site, Suining

4070196

WITHDRAWN

Research Site, Concepción

4781156

WITHDRAWN

Research Site, Temuco

41950640

NOT_YET_RECRUITING

Research Site, Salvador

91350200

NOT_YET_RECRUITING

Research Site, Porto Alegre

07601

NOT_YET_RECRUITING

Research Site, Hackensack

08043

RECRUITING

Research Site, Voorhees Township

02903

NOT_YET_RECRUITING

Research Site, Providence

29308-014

NOT_YET_RECRUITING

Research Site, Cachoeiro de Itapemirim

80810-050

NOT_YET_RECRUITING

Research Site, Curitiba

17210-120

NOT_YET_RECRUITING

Research Site, Jaú

86015-520

NOT_YET_RECRUITING

Research Site, Londrina

96020-080

NOT_YET_RECRUITING

Research Site, Pelotas

90035-000

NOT_YET_RECRUITING

Research Site, Porto Alegre

22775-001

NOT_YET_RECRUITING

Research Site, Rio de Janeiro

01246-000

NOT_YET_RECRUITING

Research Site, São Paulo

01327-001

NOT_YET_RECRUITING

Research Site, São Paulo

V2S 0C2

NOT_YET_RECRUITING

Research Site, Abbotsford

L4M 6M2

NOT_YET_RECRUITING

Research Site, Barrie

L6R 3J7

NOT_YET_RECRUITING

Research Site, Brampton

G7H 7K9

NOT_YET_RECRUITING

Research Site, Chicoutimi

M4N 3M5

NOT_YET_RECRUITING

Research Site, Toronto

FI-33521

NOT_YET_RECRUITING

Research Site, Tampere

06100

NOT_YET_RECRUITING

Research Site, Nice

H-1145

WITHDRAWN

Research Site, Budapest

110 029

NOT_YET_RECRUITING

Research Site, Ansārinagar

00144

NOT_YET_RECRUITING

Research Site, Roma

00168

NOT_YET_RECRUITING

Research Site, Roma

247-8533

NOT_YET_RECRUITING

Research Site, Kamakura-shi

371-8511

NOT_YET_RECRUITING

Research Site, Maebashi

1213 XZ

NOT_YET_RECRUITING

Research Site, Hilversum

4708 AE

NOT_YET_RECRUITING

Research Site, Roosendaal

LIMA 29

NOT_YET_RECRUITING

Research Site, Lima

Lima 34

NOT_YET_RECRUITING

Research Site, Lima

81-519

NOT_YET_RECRUITING

Research Site, Gdynia

44-101

NOT_YET_RECRUITING

Research Site, Gliwice

75-581

NOT_YET_RECRUITING

Research Site, Koszalin

30-727

NOT_YET_RECRUITING

Research Site, Krakow

97-300

NOT_YET_RECRUITING

Research Site, Piotrkow Trybunalski

61-731

NOT_YET_RECRUITING

Research Site, Poznan

35-001

NOT_YET_RECRUITING

Research Site, Rzeszów

04-073

NOT_YET_RECRUITING

Research Site, Warsaw

03080

NOT_YET_RECRUITING

Research Site, Seoul

06273

NOT_YET_RECRUITING

Research Site, Seoul

06351

NOT_YET_RECRUITING

Research Site, Seoul

06591

NOT_YET_RECRUITING

Research Site, Seoul

08041

NOT_YET_RECRUITING

Research Site, Barcelona

08208

NOT_YET_RECRUITING

Research Site, Sabadell

112 81

NOT_YET_RECRUITING

Research Site, Stockholm

141 86

NOT_YET_RECRUITING

Research Site, Stockholm

Unknown

NOT_YET_RECRUITING

Research Site, Taipei

06520

NOT_YET_RECRUITING

Research Site, Ankara

06620

NOT_YET_RECRUITING

Research Site, Ankara

AB25 2ZN

NOT_YET_RECRUITING

Research Site, Aberdeen

BS2 8ED

NOT_YET_RECRUITING

Research Site, Bristol

CB2 0QQ

NOT_YET_RECRUITING

Research Site, Cambridge

EH4 2XU

NOT_YET_RECRUITING

Research Site, Edinburgh

G12 0YN

NOT_YET_RECRUITING

Research Site, Glasgow

SW3 6JJ

NOT_YET_RECRUITING

Research Site, Greater London

EC1M6BQ

NOT_YET_RECRUITING

Research Site, London

M20 4BX

NOT_YET_RECRUITING

Research Site, Manchester

NE7 7DN

NOT_YET_RECRUITING

Research Site, Newcastle

PL6 8DH

NOT_YET_RECRUITING

Research Site, Plymouth

PR2 9HT

NOT_YET_RECRUITING

Research Site, Preston

Sponsors

Lead Sponsor

Collaborators (1)

All Listed Sponsors
collaborator

Parexel

INDUSTRY

lead

AstraZeneca

INDUSTRY

NCT06952803 - A Study of Metastases Free Survival With Saruparib vs Placebo Added to a Standard RT/ADT in Men With High-risk Prostate Cancer With a BRCA Mutation | Biotech Hunter | Biotech Hunter