A Study to Compare Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab (MK-3475) Versus Pembrolizumab Alone as Treatment in Participants With Mismatch Repair Proficient Endometrial Cancer (MK-2870-033/TroFuse-033/GOG-3119/ENGOT-en29)

PHASE3RecruitingINTERVENTIONAL
Enrollment

1,123

Participants

Timeline

Start Date

May 22, 2025

Primary Completion Date

May 24, 2032

Study Completion Date

May 24, 2032

Conditions
Endometrial Cancer
Interventions
BIOLOGICAL

Pembrolizumab

Intravenous (IV) Infusion

DRUG

Carboplatin

During the Induction Phase, participants receive carboplatin AUC 5 (mg/mL/min) on Day 1 of each 3-week cycle for 6 cycles (up to approximately 4 months) via IV infusion.

DRUG

Paclitaxel

During the Induction Phase, participants receive paclitaxel 175 mg/m2 on Day 1 of each 3-week cycle for 6 cycles (up to approximately 4 months) via IV infusion.

DRUG

Docetaxel

During the Induction Phase, participants may receive docetaxel (in place of paclitaxel) 75 mg/m2 on Day 1 of each 3-week cycle for 6 cycles (up to approximately 4 months) via IV infusion.

BIOLOGICAL

Sacituzumab Tirumotecan

IV Infusion

Trial Locations (141)

333

RECRUITING

Linkou Chang Gung Memorial Hospital ( Site 3705), Taoyuan District

704

RECRUITING

National Cheng Kung University Hospital ( Site 3702), Tainan City

1000

RECRUITING

CHU Saint-Pierre ( Site 0405), Brussels

2148

RECRUITING

Blacktown Hospital ( Site 0201), Blacktown

3000

RECRUITING

UZ Leuven ( Site 0401), Leuven

3002

RECRUITING

Epworth Freemasons ( Site 0207), Melbourne

4000

RECRUITING

CHU de Liege ( Site 0404), Liège

RECRUITING

Roskilde Sygehus ( Site 1204), Roskilde

4011

RECRUITING

Stavanger Universitetssykehus ( Site 2703), Norway

4029

RECRUITING

Royal Brisbane and Women's Hospital ( Site 0206), Brisbane

4032

RECRUITING

Debreceni Egyetem Klinikai Kozpont-Szülészeti és Nőgyógyászati Klinika ( Site 1701), Debrecen

6020

RECRUITING

Medizinische Universitaet Innsbruck-Univ.-Klinik f. Gynäkologie und Geburtshilfe ( Site 0301), Innsbruck

6060

RECRUITING

Grand Hôpital de Charleroi ( Site 0403), Charleroi

8200

RECRUITING

Aarhus Universitetshospital, Skejby ( Site 1205), Aarhus

9000

RECRUITING

AZ Maria Middelares ( Site 0402), Ghent

10002

RECRUITING

National Taiwan University Hospital ( Site 3701), Taipei

10016

RECRUITING

Laura and Isaac Perlmutter Cancer Center at NYU Langone ( Site 6004), New York

10400

RECRUITING

Ramathibodi Hospital. ( Site 3802), Bangkok

10449

RECRUITING

Mackay Memorial Hospital ( Site 3704), Taipei

10700

RECRUITING

Faculty of Medicine Siriraj Hospital ( Site 3801), Bangkok

11501

RECRUITING

Perlmutter Cancer Center at NYU Langone Hospital - Long Island ( Site 6055), Mineola

14000

RECRUITING

Centre Francois Baclesse ( Site 1412), Caen

14004

RECRUITING

Hospital Universitario Reina Sofia ( Site 3402), Córdoba

15038

RECRUITING

IPOR Instituto Peruano de Oncología & Radioterapia ( Site 2803), San Isidro

RECRUITING

INSTITUTO NACIONAL DE ENFERMEDADES NEOPLASICAS ( Site 2805), Lima

15072

RECRUITING

Clínica San Felipe ( Site 2804), Jesus Maria

17007

RECRUITING

Institut Català d'Oncologia (ICO) - Girona ( Site 3407), Girona

18015

RECRUITING

St. Luke's University Health Network ( Site 6041), Bethlehem

19104

RECRUITING

Hospital of the University of Pennsylvania ( Site 5007), Philadelphia

RECRUITING

Hospital of the University of Pennsylvania ( Site 6023), Philadelphia

20010

RECRUITING

MedStar Washington Hospital Center ( Site 5005), Washington D.C.

20141

RECRUITING

Istituto Europeo di Oncologia ( Site 2110), Milan

20520

RECRUITING

Turku University Hospital-Department of Obstetrics and Gynecology ( Site 1302), Turku

22031

RECRUITING

Inova Schar Cancer Institute ( Site 6003), Fairfax

22185

RECRUITING

Skånes Universitetssjukhus Lund ( Site 3502), Lund

28034

RECRUITING

Hospital Universitario Ramon y Cajal ( Site 3403), Madrid

28041

RECRUITING

Hospital Universitario 12 de Octubre ( Site 3404), Madrid

31059

RECRUITING

Oncopole Claudius Regaud ( Site 1407), Toulouse

31405

RECRUITING

St. Joseph's/Candler Health System ( Site 6021), Savannah

33076

RECRUITING

Institut Bergonié - Centre Régional de Lutte Contre Le Cancer de Bordeaux et Sud Ouest ( Site 1405), Bordeaux

33140

RECRUITING

Mount Sinai Cancer Center ( Site 6031), Miami Beach

33401

RECRUITING

Florida Cancer Specialists East ( Site 7001), West Palm Beach

33520

RECRUITING

Tampereen yliopistollinen sairaala ( Site 1303), Tampere

33901

RECRUITING

Florida Cancer Specialists - South ( Site 7003), Fort Myers

36604

RECRUITING

University of South Alabama, Mitchell Cancer Institute ( Site 6033), Mobile

39216

RECRUITING

St. Dominic's Hospital ( Site 5004), Jackson

40002

RECRUITING

Faculty of Medicine - Khon Kaen University ( Site 3803), Khon Kaen

40705

RECRUITING

Taichung Veterans General Hospital ( Site 3703), Taichung

42601

RECRUITING

Keimyung University Dongsan Hospital ( Site 3105), Daegu

45459

RECRUITING

Miami Valley Hospital South ( Site 6014), Centerville

46009

RECRUITING

Fundación Instituto Valenciano de Oncología ( Site 3405), Valencia

46845

RECRUITING

Parkview Research Center ( Site 6008), Fort Wayne

50134

RECRUITING

Azienda Ospedaliera Universitaria Careggi ( Site 2109), Florence

55404

RECRUITING

Minnesota Oncology Hematology, PA ( Site 8003), Minneapolis

69008

RECRUITING

CENTRE LEON BERARD ( Site 1401), Lyon

70029

RECRUITING

Kuopion Yliopistollinen Sairaala ( Site 1304), Kuopio

70433

RECRUITING

Women's Cancer Care ( Site 6010), Covington

71103

RECRUITING

TRIALS 365 ( Site 6005), Shreveport

74146

RECRUITING

Oklahoma Cancer Specialists and Research Institute, LLC ( Site 6047), Tulsa

75014

RECRUITING

Hopitaux Universitaires Paris Centre-Hopital Cochin ( Site 1411), Paris

75702

RECRUITING

Texas Oncology - Northeast Texas ( Site 8002), Tyler

76104

RECRUITING

Texas Oncology - DFW ( Site 8004), Fort Worth

78240

RECRUITING

Texas Oncology-San Antonio Medical Center ( Site 8001), San Antonio

87131

RECRUITING

University of New Mexico Comprehensive Cancer Center ( Site 6046), Albuquerque

100044

RECRUITING

Peking University Peoples Hospital ( Site 0845), Beijing

110131

RECRUITING

FUNDACION CTIC CENTRO DE TRATAMIENTO E INVESTIGACION SOBRE CANCER LUIS CARLOS SARMIENTO ANGULO ( Site 0902), Bogotá

119074

RECRUITING

National University Hospital ( Site 3202), Singapore

134021

RECRUITING

The First Hospital Of Jilin University ( Site 0815), Changchun

168583

RECRUITING

National Cancer Centre Singapore ( Site 3201), Singapore

200072

RECRUITING

Shanghai Tenth People's Hospital ( Site 0847), Shanghai

200090

RECRUITING

Obstetrics & Gynecology Hospital of Fudan University ( Site 0818), Shanghai

210006

RECRUITING

Nanjing First Hospital ( Site 0828), Nanjing

250117

RECRUITING

Shandong Cancer Hospital ( Site 0803), Jinan

310006

RECRUITING

The Affiliated Women's Hospital of Zhejiang University ( Site 0834), Hangzhou

317000

RECRUITING

Taizhou Hospital of Zhejiang Province ( Site 0809), Linhai

325015

RECRUITING

The First Affiliated Hospital of Wenzhou Medical University ( Site 0805), Wenzhou

337000

RECRUITING

Jiangxi Maternal and Child Health Hospital ( Site 0807), Nanchang

400030

RECRUITING

Chongqing University Cancer Hospital ( Site 0838), Chongqing

430023

RECRUITING

Wuhan Union Hospital Cancer Center ( Site 0824), Wuhan

510060

RECRUITING

Sun Yat-sen University Cancer Center ( Site 0846), Guangzhou

510280

RECRUITING

Zhujiang Hospital of Southern Medical University ( Site 0829), Guangzhou

515041

RECRUITING

Cancer Hospital of Shantou University Medical College ( Site 0827), Shantou

530021

RECRUITING

Guangxi Medical University Affiliated Tumor Hospital. ( Site 0825), Nanning

545006

RECRUITING

Liuzhou People's Hospital ( Site 0831), Liuzhou

644000

RECRUITING

The Second People's Hospital of Yibin ( Site 0840), Yibin

660001

RECRUITING

Oncologos Del Occidente ( Site 0907), Pereira

710061

RECRUITING

The First Affiliated Hospital of Xi'an Jiaotong University ( Site 0816), Xi'an

2520598

RECRUITING

ONCOCENTRO APYS ( Site 0704), Viña del Mar

3109601

RECRUITING

Rambam Health Care Campus ( Site 2025), Haifa

3436212

RECRUITING

Carmel Hospital ( Site 2023), Haifa

6423906

RECRUITING

Sourasky Medical Center ( Site 2022), Tel Aviv

7500653

RECRUITING

Centro de Estudios Clínicos SAGA ( Site 0708), Santiago

7500921

RECRUITING

FALP ( Site 0702), Santiago

8330024

RECRUITING

Pontificia Universidad Catolica de Chile ( Site 0705), Santiago

8420383

RECRUITING

Bradfordhill ( Site 0703), Santiago

9103102

RECRUITING

Shaare Zedek Medical Center ( Site 2020), Jerusalem

04074

RECRUITING

Maine Medical Center - Scarborough Campus ( Site 6042), Scarborough

07666

RECRUITING

Holy Name Medical Center ( Site 6011), Teaneck

02905

RECRUITING

Women & Infants Hospital ( Site 5003), Providence

C1426ANZ

RECRUITING

Instituto Alexander Fleming ( Site 0105), Ciudad Autónoma de Buenos Aires

B7600FZO

RECRUITING

Instituto de Investigaciones Clínicas Mar del Plata ( Site 0108), Mar del Plata

C1426AAL

RECRUITING

Fundación Respirar ( Site 0101), Buenos Aires

C1280AEB

RECRUITING

Hospital Británico de Buenos Aires ( Site 0103), CABA

J5400EBB

RECRUITING

Instituto San Marcos ( Site 0106), San Juan

04014-002

RECRUITING

IBCC - Instituto Brasileiro de Controle do Câncer ( Site 0525), São Paulo

H2X 0C1

RECRUITING

Centre Hospitalier de l Universite de Montreal - CHUM ( Site 0605), Montreal

H3T 1E2

RECRUITING

Jewish General Hospital ( Site 0606), Montreal

H4A 3J1

RECRUITING

McGill University Health Centre ( Site 0604), Montreal

J1H 5N4

RECRUITING

CIUSSS de l Estrie - CHUS - Centre Hosp. Univ. Sherbrooke ( Site 0608), Sherbrooke

050025

RECRUITING

Instituto de Cancerología S.A.S ( Site 0904), Medellín

050030

RECRUITING

Fundacion Colombiana de Cancerología Clinica Vida ( Site 0905), Medellín

128 08

RECRUITING

Vseobecna fakultni nemocnice v Praze-Gynekologicko-porodnicka klinika 1.LF a VFN ( Site 1101), Prague

00029

RECRUITING

Helsinki University Hospital - Comprehensive Cancer Center (HYKS - Syöpäkeskus) ( Site 1301), Helsinki

115 28

RECRUITING

Alexandra General Hospital of Athens ( Site 1604), Athens

003-0804

RECRUITING

National Hospital Organization Hokkaido Cancer Center ( Site 2212), Sapporo

673-8558

RECRUITING

Hyogo Cancer Center ( Site 2216), Akashi

028-3695

RECRUITING

Iwate Medical University Hospital ( Site 2207), Shiwa-gun

350-1298

RECRUITING

Saitama Medical University International Medical Center ( Site 2201), Hidaka

135-8550

RECRUITING

Cancer Institute Hospital of JFCR ( Site 2208), Koto

160-8582

RECRUITING

Keio University Hospital ( Site 2209), Shinjuku

811-1395

RECRUITING

National Hospital Organization Kyushu Cancer Center ( Site 2203), Fukuoka

951-8566

RECRUITING

Niigata Cancer Center Hospital ( Site 2210), Niigata

0379

RECRUITING

Oslo universitetssykehus, Radiumhospitalet ( Site 2701), Oslo

60-569

RECRUITING

Uniwersytecki Szpital Kliniczny w Poznaniu ( Site 3011), Poznan

61-866

RECRUITING

Wielkopolskie Centrum Onkologii im. Marii Skłodowskiej-Curie ( Site 3003), Poznan

08-110

RECRUITING

Mazowiecki Szpital Wojewódzki w Siedlcach-Siedleckie Centrum Onkologii ( Site 3004), Siedlce

02-781

RECRUITING

Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie ( Site 3002), Warsaw

44-101

RECRUITING

Narodowy Instytut Onkologii - Oddzial w Gliwicach ( Site 3006), Gliwice

25-734

RECRUITING

Swietokrzyskie Centrum Onkologii. ( Site 3008), Kielce

00917

RECRUITING

Puerto Rico Cancer Specialists Clinical Trials ( Site 4201), San Juan

03080

RECRUITING

Seoul National University Hospital ( Site 3102), Seoul

03722

RECRUITING

Severance Hospital, Yonsei University Health System ( Site 3101), Seoul

05505

RECRUITING

Asan Medical Center ( Site 3103), Seoul

08908

RECRUITING

Institut Català d'Oncologia - L'Hospitalet ( Site 3408), L'Hospitalet de Llobregat

08035

RECRUITING

Hospital Universitari Vall d''Hebron ( Site 3401), Barcelona

751 85

RECRUITING

Akademiska Sjukhuset ( Site 3501), Uppsala

BN2 1ES

RECRUITING

University Hospitals Sussex NHS Foundation Trust ( Site 4011), East Sussex

SW3 6JJ

RECRUITING

ROYAL MARSDEN HOSPITAL (CHELSEA) ( Site 4006), London

EH4 2XU

RECRUITING

Western General Hospital ( Site 4012), Edinburgh

SM3 5PT

RECRUITING

Royal Marsden Hospital (Sutton) ( Site 4005), London

M20 4BX

RECRUITING

The Christie NHS Foundation Trust ( Site 4003), Manchester

All Listed Sponsors
lead

Merck Sharp & Dohme LLC

INDUSTRY