Effectiveness of Exparel Anesthetic Administered by the Surgeon During Knee Surgery

NARecruitingINTERVENTIONAL
Enrollment

60

Participants

Timeline

Start Date

August 18, 2025

Primary Completion Date

December 11, 2026

Study Completion Date

December 11, 2026

Conditions
Total Knee Arthroplasty
Interventions
PROCEDURE

Intra-articular Posteromedial Surgeon Administered (IPSA) Block of EXPAREL

"Patients in this group will receive IPSA block and Local Infiltration Analgesia (LIA).~IPSA block is a pain numbing medication given by surgeon and injected inside the back and inner side of the knee joint. Local Infiltration Analgesia is a pain numbing medication injection given by the surgeon around the surgical knee area. The medications used in the procedure will be EXPAREL, and Bupivacaine HCL."

PROCEDURE

Adductor Canal Block (ACB) and Local Local Infiltration Analgesia of EXPAREL

ACB is a pain numbing injection given by anesthesiologist near the adductor canal, a passage in the mid-thigh that contains nerves connecting the knee region. Local Infiltration Analgesia is a pain numbing medication injection given by the surgeon around the surgical knee area. The medications used in the procedure will be EXPAREL, and Bupivacaine HCL.

PROCEDURE

Local Infiltration Analgesia (LIA) of EXPAREL

Local Infiltration Analgesia is a pain numbing medication injection given by the surgeon around the surgical knee area. The medications used in the procedure will be EXPAREL, and Bupivacaine HCL.

Trial Locations (1)

44113

RECRUITING

Cleveland Clinic Lutheran Hospital, Cleveland

Sponsors
All Listed Sponsors
collaborator

Pacira Pharmaceuticals, Inc

INDUSTRY

lead

The Cleveland Clinic

OTHER