The Effect of Oxytocin Nasal Spray on Preventing Postoperative Delirium in Elderly Patients Undergoing Orthopedic Surgery

PHASE2Not yet recruitingINTERVENTIONAL
Enrollment

220

Participants

Timeline

Start Date

June 1, 2025

Primary Completion Date

June 1, 2026

Study Completion Date

June 30, 2026

Conditions
Cervical Spinal StenosisThoracic Spinal StenosisLumbar Spinal StenosisRotator Cuff InjuryFemoral Head NecrosisSpinal TraumaKnee Joint Injury
Interventions
DRUG

oxytocin nasal spray

Cases were included according to the inclusion and exclusion criteria, and induction, maintenance and resuscitation were performed according to the standard protocol for general anesthesia.Before the end of anesthesia, the experimenter administered oxytocin nasal spray (Oxytocin) that was 3 sprays in each nostril (4 IU each) for a total of 24 IU. Beginning 1 day postoperatively, administer 24 IU of oxytocin nasal spray 2 times/day in the morning and 24 IU in the evening.Until 7 days after surgery or discharge.

Trial Locations (1)

310000

The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou

All Listed Sponsors
lead

Zhejiang University

OTHER