Bleomycin as an Effective and Curative Adjunct Therapy for Lymphangioma

CompletedOBSERVATIONAL
Enrollment

809

Participants

Timeline

Start Date

January 1, 2018

Primary Completion Date

December 31, 2022

Study Completion Date

February 4, 2025

Conditions
LymphangiomaLymphatic Malformations
Interventions
DRUG

Sclerotherapy with intralesional bleomycin injection

The intervention studied is intralesional Bleomycin injection, which involves the direct injection of Bleomycin, a chemotherapeutic agent, into the lymphangioma lesions. This minimally invasive procedure is aimed at reducing the size of the lymphangioma by disrupting the abnormal growth of lymphatic vessels. The dosage of Bleomycin is tailored based on the patient's body weight, typically ranging from 1 to 3 mg per kg of body weight per injection. The intervention is distinct from other treatments, such as surgical excision or other sclerotherapy agents, as it specifically utilizes Bleomycin's mechanism of action to induce tissue sclerosis and promote lesion regression without the need for invasive surgery. This intervention may require multiple treatment sessions, depending on the size, location of the lymphangioma, and individual's response to therapy, with the goal of achieving long-term effectiveness and improving cosmetic outcomes.

Trial Locations (1)

Unknown

Department of Surgery, The National Children Hospital, Hanoi, Hanoi

All Listed Sponsors
lead

National Children's Hospital, Vietnam

OTHER

NCT06943703 - Bleomycin as an Effective and Curative Adjunct Therapy for Lymphangioma | Biotech Hunter | Biotech Hunter