Evaluation of Polygenic Risk Score for Epithelial OVarian cancEr Risk Prediction: the PROVE Study

RecruitingOBSERVATIONAL
Enrollment

1,300

Participants

Timeline

Start Date

June 1, 2025

Primary Completion Date

September 30, 2026

Study Completion Date

December 1, 2026

Conditions
Ovarian Cancer
Interventions
GENETIC

Polygenic Risk Score

For the PRS analysis, SNPs for genotyping will be selected based on the latest findings from GWAS on EOC, particularly leveraging the results, as reported by Dareng et al. (doi:10.1038/s41431-021-00987-7). The PRS will be calculated as a weighted sum of risk alleles based on the selected SNPs.

Trial Locations (1)

00168

RECRUITING

Dipartimento Universitario di Scienze della Vita e Sanità Pubblica, Roma

All Listed Sponsors
lead

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

OTHER

NCT06935344 - Evaluation of Polygenic Risk Score for Epithelial OVarian cancEr Risk Prediction: the PROVE Study | Biotech Hunter | Biotech Hunter