LE + CC vs. LE for Ovulation Induction

NARecruitingINTERVENTIONAL
Enrollment

600

Participants

Timeline

Start Date

April 28, 2025

Primary Completion Date

June 30, 2027

Study Completion Date

June 30, 2027

Conditions
LetrozoleClomiphene CitrateOvulation DisorderOvulation Induction
Interventions
PROCEDURE

IUI or intercourse

5 milligrams LE per day (Femara® 2.5 milligrams, Novartis, Switzerland) and 50 milligrams CC (Duinum 50 milligrams, Medochemie, Cyprus) or 5 milligrams LE per day (Femara® 2.5 milligrams, Novartis, Switzerland) will be started on the second to the fourth day of the cycle, for five consecutive days. An ultrasound will be carried out three days after the last dose of medicine (day 8 of OI) to evaluate ovarian follicles' growth and the endometrium's thickness. If the follicular diameter reach ≥14 millimetres, check-up will be planned every two days until it reaches 18 millimetres. If there is the appearance of at least one follicle reaching 18 millimetres or more, a human chorionic gonadotropin (hCG) injection (IVF-C 5000 IU, LG Life Science, Korea) will be administered on the same day of the ultrasound in order to induce ovulation. IUI will be scheduled 36 - 38 hours after hCG injection or intercourse will be scheduled in the next day.

Trial Locations (1)

70000

RECRUITING

My Duc Hospital, Ho Chi Minh City

All Listed Sponsors
lead

Mỹ Đức Hospital

OTHER