A Study to Assess Efficacy and Safety of JNJ-77242113 Compared to Placebo and Ustekinumab in Participants With Moderate to Severe Plaque Psoriasis

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

752

Participants

Timeline

Start Date

April 15, 2025

Primary Completion Date

March 30, 2026

Study Completion Date

August 20, 2027

Conditions
Plaque Psoriasis
Interventions
DRUG

JNJ-77242113

JNJ-77242113 will be administered orally.

DRUG

Matching Placebo to JNJ-77242113

Matching placebo will be administered orally.

DRUG

Ustekinumab

Ustekinumab will be administered subcutaneously.

DRUG

Matching Placebo to Ustekinumab

Matching placebo will be administered subcutaneously.

Trial Locations (160)

1036

Obudai Egeszsegugyi Centrum Kft, Budapest

1090

Allgemeines Krankenhaus der Stadt Wien, Vienna

UZ Brussel, Brussels

1152

Uno Medical Trials Ltd., Budapest

2145

Westmead Hospital, Westmead

2217

Premier Specialists, Kogarah

2400

Bispebjerg Hospital, København NV

2900

Gentofte Hospital, Hellerup

3000

Universitair Ziekenhuis Leuven, Leuven

3004

The Alfred Hospital, Melbourne

3050

Royal Melbourne Hospital, Melbourne

3100

Universtitatsklinikum St Polten, Sankt Pölten

3132

ISHI dermatology, Mitcham

3168

Monash Medical Centre, Clayton

3200

Gyongyosi Bugat Pal Korhaz, Gyöngyös

4000

Centre Hospitalier Universitaire de Liege Domaine Universitaire du Sart Tilman, Liège

Sjællands University hospital, Roskilde

4020

Kepler Universitatsklinikum GmbH, Linz

4031

Derma-B Kft, Debrecen

4032

Debreceni Egyetem Klinikai Kozpont, Debrecen

4102

Veracity Clinical Research, Woolloongabba

4151

Cornerstone Dermatology, Coorparoo

5000

Odense University Hospital, Odense

Allergo-Derm Bakos Kft., Szolnok

5700

Synexus Magyarorszag Kft, Gyula

6000

Bacs-kiskun Megyei Korhaz, Kecskemét

6800

LKH Feldkirch, Feldkirch

Porcika Klinika - Vasarhelyi Sarkanyfu Kft., Hódmezővásárhely

7400

Somogy Varmegyei Kaposi Mor Oktato Korhaz, Kaposvár

8200

Aarhus University Hospital, Aarhus

Medmare Egeszsegugyi Es Szolgaltato Bt., Veszprém

9000

AZ St. Lucas, Ghent

Ghent University Hospital, Ghent

9100

Aalborg Sygehus Syd, Aalborg

9990

Dermatologie Maldegem, Maldegem

10028

Mount Sinai Doctors Dermatology, New York

10075

Sadick Research Group, New York

10789

ISA - Interdisciplinary Study Association GmbH, Berlin

15213

UPMC Department of Dermatology, Pittsburgh

15706

Hosp. Clinico Univ. de Santiago, Santiago Compostela

15831

Dermatologie Mahlow, Mahlow

18016

Hosp. Univ. San Cecilio, Granada

19114

Clinical Research Philadelphia, Philadelphia

24105

Universitaetsklinikum Schleswig Holstein Campus Kiel, Kiel

28006

Grupo Dermatologico Y Estetico Pedro Jaen, Madrid

Hosp. Univ. de La Princesa, Madrid

28041

Hosp. Univ. 12 de Octubre, Madrid

28405

Wilmington Dermatology Center, Wilmington

30022

Hamilton Research LLC, Alpharetta

33134

Driven Research LLC, Coral Gables

33155

Bioclinical Research Alliance Inc., Miami

33613

Forcare Clinical Research Inc, Tampa

34470

Renstar Medical Research, Ocala

35244

Cahaba Research Inc, Birmingham

37211

Advanced Research Experts PLLC, Nashville

41009

Hosp. Virgen Macarena, Seville

41014

Hosp. Ntra. Sra. de Valme, Seville

42104

Equity Medical, Bowling Green

44124

Apex Dermatology Mayfield Heights, Mayfield Heights

44512

Optima Research, Boardman

46026

Hosp. Univ. I Politecni La Fe, Valencia

46168

Indiana Clinical Trial Center, Plainfield

46940

Hosp. de Manises, Manises

48059

Hamzavi Dermatology, Fort Gratiot

48084

Somerset Skin Centre, Troy

48149

Universitaetsklinikum Muenster, Münster

48202

Henry Ford Hospital, Detroit

48455

Fachklinik Bad Bentheim, Bad Bentheim

48902

Hosp. Univ. de Cruces, Barakaldo

49316

The Derm Institute of West Michigan, Caledonia

49565

Studienzentrum an der Hase GbR, Bramsche

50009

Hosp. Clinico Univ. Lozano Blesa, Zaragoza

Hosp. Univ. Miguel Servet, Zaragoza

52242

University of Iowa, Iowa City

53127

Universitatsklinikum Bonn, Bonn

55112

Minnesota Clinical Study Center, New Brighton

55128

Gemeinschaftspraxis Dres. Quist, Mainz

57702

Health Concepts, Rapid City

58453

Hautarztpraxis, Witten

60076

Northshore Medical Group, Skokie

63501

Cleaver Dermatology, Kirksville

64283

Rosenpark Research GmbH, Darmstadt

64506

MediSearch Clinical Trials, Saint Joseph

75231

Modern Research Associates PLLC, Dallas

76011

Arlington Research Center, Inc., Arlington

77004

Center for Clinical Studies, Houston

77598

Center for Clinical Studies, Webster

78213

Progressive Clinical Research, San Antonio

78218

Texas Dermatology and Laser Specialists, San Antonio

84120

Kalo Clinical Research, West Valley City

86179

Klinikum Augsburg, Augsburg

88045

Derma-Study-Center Friedrichshafen GmbH, Friedrichshafen

89129

Studienzentrum Dr Schwarz Germany, Langenau

91342

Olive View-UCLA Education & Research Institute, Sylmar

91436

T Joseph Raoof Md Inc, Encino

92024

California Dermatology & Clinical Research Institute, Encinitas

92056

Dermatologist Medical Group of North County, Inc., Oceanside

92103

MedDerm Associates, San Diego

92701

Southern California Dermatology, Santa Ana

92708

First OC Dermatology, Fountain Valley

95765

NorCal Clinical Research, Rocklin

95815

Integrative Skin Science and Research, Sacramento

97201

Oregon Medical Research Center, Portland

97210

Oregon Dermatology and Research Center, Portland

98012

Frontier Derm Partners CRO, LLC, Mill Creek

06030

University of Conn Health Center, Farmington

02111

Tufts Medical Center, Boston

02135

Metro Boston Clinical Partners, Brighton

X5000

Consultora Integral de Salud SRL, Barrio Gral Paz Cba Capital

B1643CRO

Instituto Medico De Alta Complejidad (IMAC), Buenos Aires

C1417EYG

Mindout Research, Buenos Aires

C1425

Instituto de Neumonologia y Dermatologia, Buenos Aires

C1055AAO

Buenos Aires Skin, CABA

C1056ABH

Investigaciones Medicas IMOBA SRL, CABA

C1061AAS

CIPREC, CABA

C1122AAF

Halitus Instituto Medico S.A. - Dermatologia y Estetica, Caba

C1128

Mautalen Salud e Investigacion, CABA

C1199ABB

Hospital Italiano de Buenos Aires, CABA

S2000DBS

Instituto De Especialidades De La Salud SRL, Rosario

B1646

MR Medicina Reumatologica, San Fernando

T4000

Instituto de Investigaciones Medicas Tucuman, San Miguel de Tucumán

A1E 1V4

Skincare Studio Inc Dermatology Clinical Trials, St. John's

L1S7K8

CCA Medical Research Corporation, Ajax

L4M 7G1

SimcoDerm Medical and Surgical Dermatology Centre, Barrie

L8N 1Y2

Dermatrials Research, Hamilton

N6A 5R9

Lovegrove Dermatology, London

L3P 1X3

Lynderm Research Inc., Markham

N2J 1C4

Alliance Clinical Trials, Waterloo

H2X 2V1

Innovaderm Research Inc., Montreal

G1W 4R4

The Centre de recherche Saint-Louis, Québec

01307

Medizinische Fakultaet Carl Gustav Carus Technische Universitaet Dresden, Dresden

15 375

Specderm Poznanska sp j, Bialystok

15-351

Osteo-Medic s.c A. Racewicz, J Supronik, Bialystok

82 300

Centrum Kliniczno Badawcze J Brzezicki B Gornikiewicz Brzezicka Lekarze Spolka Partnerska, Elblag

40 568

Care Clinic Sp z o o, Katowice

30 002

Specjalistyczny gabinet dermatologiczny Aplikacyjno Badawczy Marek Brzewski Pawel Brzewski Spolka Cywilna, Krakow

90-265

Dermed Centrum Medyczne Sp z o o, Lodz

10-117

Etyka Osrodek Badan Klinicznych, Olsztyn

60 529

SOLUMED Centrum Medyczne, Poznan

96 100

Velocity Skierniewice sp z o o, Skierniewice

02 661

Magdalena Opadczuk Carpe Diem Centrum Medycyny Estetycznej, Warsaw

02 953

Klinika Ambroziak Dermatologia, Warsaw

51 685

WroMedica, Wroclaw

52 416

Centrum Medyczne Oporow, Wroclaw

4835 044

Uls Alto Ave - Hosp. Sra. Da Oliveira Guimaraes, Braga

2410 197

Unidade Local De Saude Da Regiao De Leiria Epe, Leiria

1169 050

Uls Sao Jose - Hosp. Sto Antonio Dos Capuchos, Lisbon

1998 018

Hosp. Cuf Descobertas, Lisbon

4099 001

Ulssa Hosp. Santo Antonio, Porto

03010

Hosp. Gral. Univ. Dr. Balmis, Alicante

08036

Hosp. Clinic de Barcelona, Barcelona

03570

Hosp. de La Marina Baixa, Villajoyosa

DY1 2HQ

Dudley Group NHS Foundation Trust, Dudley

HA1 3UJ

London North West University Healthcare NHS Trust, Harrow

PE30 4ET

The Queen Elizabeth Hospital NHS Foundation Trust, Kings Lynn

SE1 9RT

Guys and St Thomas NHS Foundation Trust, London

RG1 5AN

Royal Berkshire Hospital, Reading

M6 8HD

Salford Royal Hospital, Salford

So166yd

University Hospital Southampton, Southampton

WF1 4DG

Mid Yorkshire NHS Trust, Wakefield

All Listed Sponsors
lead

Janssen Research & Development, LLC

INDUSTRY

NCT06934226 - A Study to Assess Efficacy and Safety of JNJ-77242113 Compared to Placebo and Ustekinumab in Participants With Moderate to Severe Plaque Psoriasis | Biotech Hunter | Biotech Hunter