NCT06930391View on ClinicalTrials.gov

Effect of Extracellular Calcium on Carbetocin Mediated Contractility in Human Myometrium

NARecruitingINTERVENTIONAL
Enrollment

40

Participants

Timeline

Start Date

September 15, 2025

Primary Completion Date

June 30, 2026

Study Completion Date

June 30, 2026

Conditions
Postpartum Hemorrhage (Primary)
Interventions
DRUG

Oxytocin

Oxytocin 10-5M will be added to 3 groups of myometrial strips for 2 hours to induce desensitization.

DRUG

Carbetocin

Increasing concentrations of carbetocin in a pattern of 1 log molar increase every 10 min, from 10-10 M to 10-5 M

DRUG

Calcium

Calcium chloride in the following concentrations:1.25mM, 2.5mM and 5.0mM.

Trial Locations (1)

M5G1X5

RECRUITING

Mount Sinai Hospital, Toronto

All Listed Sponsors
lead

Samuel Lunenfeld Research Institute, Mount Sinai Hospital

OTHER

NCT06930391 - Effect of Extracellular Calcium on Carbetocin Mediated Contractility in Human Myometrium | Biotech Hunter | Biotech Hunter