PVI Alone vs PVI With Posterior Wall Isolation for Pulse-Field Ablation in Persistent AF

NANot yet recruitingINTERVENTIONAL
Enrollment

214

Participants

Timeline

Start Date

May 1, 2025

Primary Completion Date

May 1, 2027

Study Completion Date

October 1, 2027

Conditions
Atrial Fibrillation (AF)
Interventions
PROCEDURE

Pulmonary Vein Isolation

"1. Pulmonary vein isolation (PVI) is performed as the primary procedure.~2. After PVI, direct current (DC) cardioversion is performed to restore normal sinus rhythm. If the patient converts to sinus rhythm, they are randomly assigned to either the PVI-only group or the additional left atrial posterior wall ablation group.~3. Patients who fail to convert to sinus rhythm after DC cardioversion are excluded from randomization."

PROCEDURE

Additional Left Atrial Posterior Wall Ablation

"1. Additional left atrial posterior wall ablation is performed.~2. Complete electrical isolation of the entire left atrial posterior wall is confirmed (posterior box lesion isolation must be achieved).~3. Post-procedural rhythm monitoring follows the study protocol."

PROCEDURE

Non-PV trigger test

"1. If atrial fibrillation triggers are identified with isoproterenol infusion, additional focal ablation is performed.~2. Post-procedural rhythm monitoring follows the study protocol."

Trial Locations (1)

Unknown

Ewha Womans University Mokdong Hospitoal, Seoul

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Ewha Womans University Seoul Hospital

OTHER

collaborator

Korea University Anam Hospital

OTHER

collaborator

Ajou University School of Medicine

OTHER

collaborator

Seoul National University Bundang Hospital

OTHER

collaborator

Kangbuk Samsung Hospital

OTHER

collaborator

Hanyang University Seoul Hospital

OTHER

collaborator

Asan Medical Center

OTHER

collaborator

Wonkwang University Hospital

OTHER

collaborator

Korea University Guro Hospital

OTHER

collaborator

Severance Hospital

OTHER

collaborator

Eunpyeong St. Mary's Hospital

OTHER

lead

Ewha Womans University Mokdong Hospital

OTHER

NCT06929897 - PVI Alone vs PVI With Posterior Wall Isolation for Pulse-Field Ablation in Persistent AF | Biotech Hunter | Biotech Hunter