Between the Belly and the Brain: Distorted Gut-brain Crosstalk in Early-life Adversity

Not yet recruitingOBSERVATIONAL
Enrollment

50

Participants

Timeline

Start Date

May 31, 2025

Primary Completion Date

April 30, 2026

Study Completion Date

June 30, 2026

Conditions
Early Life AdversityMicrobiome, HumanAnxiety SymptomsDepressive SymptomsPosttraumatic Stress Symptoms
Interventions
DIAGNOSTIC_TEST

Completion of questionnaires; child psychiatric screening; faecal sample analysis

"Completion of questionnaires:~* FFQ (Food Frequency Questionnaire) - completed by child~* KIDSCREEN-10 - completed by child~* CRIES-13 (Child Revised Impact of Events Scale) - completed by parents/guardian and child~* CTES (Childhood Trust Events Survey) - completed by parents/guardian~* RCADS-25 (Revised Children's Anxiety and Depression Scale) - completed by parents/guardian and child~Child psychiatric screening using SCID-5-Junior - semi-structured interview conducted with child and parent(s)/guardian~Faecal sample analysis:~* Beta-diversity (UniFrac and Bray-Curtis distance index)~* Firmicutes/Bacteroidetes ratio~* Abundance of Prevotella, Lactobacillaceae, Bifidobacteriacae and Lachnospiraceae~* Short-chain fatty acid metabolites"

Trial Locations (1)

1090

UZ Brussel, Jette

All Listed Sponsors
lead

Universitair Ziekenhuis Brussel

OTHER

NCT06922773 - Between the Belly and the Brain: Distorted Gut-brain Crosstalk in Early-life Adversity | Biotech Hunter | Biotech Hunter