The COSMYC Trial (COmbined Suppression of MYC)

One ZEN-3694 pill (48 mg) will be taken each day of each BATZEN cycle.

On day 1 of each BATZEN cycle testosterone cypionate (400 mg) injection to the buttocks will be administered.

Enzalutamide 160 mg (four 40 mg capsules) taken daily by mouth on each ZENZA cycle.

Patients will continue on ADT with LHRH agonist (i.e. Zoladex, Trelstar, Eligard or Lupron) or LHRH antagonist (Degarelix or Relugolix) if not surgically castrated throughout the duration of the study to inhibit endogenous testosterone production.