Treating Intraoperative Bradycardia in Non-cardiac Surgery Patients With Atropine at Heart Rates Below 60 Versus 30 Beats Per Minute and Norepinephrine Requirements

NARecruitingINTERVENTIONAL
Enrollment

186

Participants

Timeline

Start Date

April 7, 2025

Primary Completion Date

February 28, 2026

Study Completion Date

February 28, 2026

Conditions
Intraoperative Bradycardia
Interventions
DRUG

Giving atropine at heart rates below 60 beats per minute

In patients assigned to the atropine therapy at heart rates below 60 beats per minute, atropine will be given at a dose of 0.5 mg when heart rate is below 60 beats per minute for one continuous minute. A second and third atropine dose of 0.5 mg will be given if heart rate remains or again drops below 60 beats per minute for one continuous minute. Patients will not be given more than 1.5 mg atropine.

DRUG

Giving atropine at heart rates below 30 beats per minute

In patients assigned to atropine therapy at heart rates below 30 beats per minute, atropine will be given at a dose of 0.5 mg when heart rate is below 30 beats per minute for one continuous minute. A second and third atropine dose of 0.5 mg will be given if heart rate remains or again drops below 30 beats per minute for one continuous minute. Patients will not be given more than 1.5 mg atropine.

Trial Locations (1)

20246

RECRUITING

University Medical Center Hamburg-Eppendorf, Hamburg

All Listed Sponsors
lead

University of Hamburg-Eppendorf

OTHER