Effects of Esketamine Versus Magnesium Sulfate on Emotional State and Postoperative Pain in Patients Undergoing Nasal Endoscopic Surgery

PHASE1/PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

144

Participants

Timeline

Start Date

March 1, 2025

Primary Completion Date

July 1, 2025

Study Completion Date

July 20, 2025

Conditions
Chronic RhinosinusitisEnhanced Recovery After Surgery
Interventions
DRUG

Esketamine

Intravenous esketamine 0.25 mg/kg was administered 10 min before induction of anaesthesia, followed by continuous pumping at 0.25 mg/(kg-h) until the end of the operation.

DRUG

Magnesium sulfate

Intravenous magnesium sulphate 30 mg/kg was administered within 10 min before induction of anaesthesia, followed by continuous pumping at 30 mg/(kg-h) until the end of the operation

DRUG

Saline

Pumping equal volumes of saline over the same time period

Trial Locations (1)

Unknown

The Affiliated Huaian Hospital of Xuzhou Medical University, Huai'an Second Hospital, Huaian

All Listed Sponsors
lead

The Second People's Hospital of Huai'an

OTHER