HILT Dose Optimization for Knee Osteoarthritis Pain

NARecruitingINTERVENTIONAL
Enrollment

140

Participants

Timeline

Start Date

April 23, 2025

Primary Completion Date

March 1, 2027

Study Completion Date

June 1, 2027

Conditions
Knee Osteoarthritis
Interventions
DEVICE

Low-Dose High-Intensity Laser Therapy (10 J/cm²)

Application of HILT using an Nd:YAG laser (BTL-6000, 1064 nm). Delivered via continuous scanning technique (1 cm distance) to 5 zones (25 cm² each) covering anterior, medial, and lateral knee aspects. Target dose: 10 J/cm² per zone. Session frequency: 3x/week for 4 weeks (12 total). Session duration: 15-20 min. Administered by trained PTs in outpatient rehab. Skin temperature monitored.

DEVICE

Medium-Dose High-Intensity Laser Therapy (15 J/cm²)

Application of HILT using an Nd:YAG laser (BTL-6000, 1064 nm). Delivered via continuous scanning technique (1 cm distance) to 5 zones (25 cm² each) covering anterior, medial, and lateral knee aspects. Target dose: 15 J/cm² per zone. Session frequency: 3x/week for 4 weeks (12 total). Session duration: 15-20 min. Administered by trained PTs in outpatient rehab. Skin temperature monitored.

DEVICE

High-Dose High-Intensity Laser Therapy (20 J/cm²)

Application of HILT using an Nd:YAG laser (BTL-6000, 1064 nm). Delivered via continuous scanning technique (1 cm distance) to 5 zones (25 cm² each) covering anterior, medial, and lateral knee aspects. Target dose: 20 J/cm² per zone. Session frequency: 3x/week for 4 weeks (12 total). Session duration: 15-20 min. Administered by trained PTs in outpatient rehab. Skin temperature monitored.

DEVICE

Sham High-Intensity Laser Therapy

Sham procedure mimicking active HILT using the same Nd:YAG laser device (BTL-6000). Same setup, patient positioning, scanning technique over identical zones, and session duration/frequency (3x/week, 4 weeks, 15-20 min). Device powered on with visual/auditory cues active, but no laser energy emitted. Administered by trained PTs in outpatient rehab. Skin temperature monitored.

Trial Locations (1)

12311

RECRUITING

Faculty of Physical Therapy, Al Hayah University, Cairo

All Listed Sponsors
lead

Al Hayah University In Cairo

OTHER