5,700
Participants
Start Date
April 10, 2025
Primary Completion Date
March 31, 2027
Study Completion Date
March 31, 2027
Invitation of all participants to CCS according to the standard of care (active comparator)
Invitation of all participants to CCS according to the standard of care
Invitation of all participants to CCS through self-sampling
"A self-sampling kit mailed to the participants, with a prepaid envelope for returning them after sample collection. Participants may also return the kits by depositing them in a container that will be available in their Health Care Center.~The invitation for CCS through self-sampling is accompanied by written instructions, SMS reminders and navigation support (dedicated telephone line, WhatsApp, website)"
Invitation of all participants to CCS, asking them to choose between self-sampling and the standard of care
In a telephone contact, prompted by an SMS, participants will be given the opportunity to schedule CCS according to the standard of care or to ask for a self-sampling kit to be mailed to them. Depending on their choice, the procedure will be similar to what is described for arm SOC or for arm SS, as applicable
Invitation of all participants to CCS according to the standard of care, followed by invitation of those non-adherent to CCS through self-sampling
Participants not adhering to CCS after the first invitation (SOC) will be additionally invited for CCS screening through self-sampling (as in SS)
Invitation of all participants to CCS through self-sampling, followed by invitation of those non-adherent to CCS according to the standard of care
Participants not adhering to CCS after the first invitation for self-sampling (SS) will be additionally invited for CCS screening according to the standard of care (as in SOC)
Invitation of all participants to CCS, asking them to choose between self-sampling and the standard of care; this mode of invitation is repeated when participants do not adhere to the first invitation
Participants not adhering to CCS after a first invitation for screening through a method of their choice (CHOICE) will be invited again, also being given the opportunity to choose between the standard of care or self-sampling (as in the first CHOICE invitation). Depending on the participants' choice, the procedure will be similar to what is described for arm SOC or for arm SS, as applicable, both in the first and in the second CHOICE invitations
Unidade Local de Saúde Gaia e Espinho, Vila Nova de Gaia
Instituto Portugues de Oncologia, Francisco Gentil, Porto
OTHER
Universidade do Porto
OTHER
Unidade Local de Saude de Gaia e Espinho EPE
OTHER
Instituto de Saude Publica da Universidade do Porto
OTHER