Endothelial Dysfunction for Prognosis In Patients With preeClampSia

RecruitingOBSERVATIONAL
Enrollment

385

Participants

Timeline

Start Date

May 8, 2025

Primary Completion Date

December 31, 2026

Study Completion Date

July 31, 2027

Conditions
Preeclampsia (PE)Hypertensive Disorder of Pregnancy
Interventions
DIAGNOSTIC_TEST

Hyperspectral imaging

"Hyperspectral imaging will be performed at study inclusion and will be repeated longitudinally every 1-2 days until delivery and on the first and second day after delivery. After a baseline measurement, a blood pressure cuff is inflated on the upper arm to 50 mmHg above the systolic blood pressure for 5 minutes, and then the hyperspectral imaging measurement is repeated.~Blood samples are collected at study inclusion and on the first and second day after delivery and are processed within the Department of Gynecology and Obstetrics of the Heidelberg University Hospital."

DIAGNOSTIC_TEST

Further markers of endothelial dysfunction

"At study inclusion: 1. blood samples will be collected for the measurement of EASIX and cardiac/endothelial markers; 2. sublingual in vivo microscopy will be performed (requires about 20 minutes and can be compared to a sublingual temperature measurement); 3. Doppler ultrasound will be performed to evaluate uterine and ophthalmic arteries.~Blood samples will also be collected at the first and second day after delivery."

Trial Locations (1)

69120

RECRUITING

Heidelberg University Hospital, Department of Gynecology and Obstetrics, Heidelberg

All Listed Sponsors
lead

Heidelberg University

OTHER