116
Participants
Start Date
March 25, 2025
Primary Completion Date
June 30, 2026
Study Completion Date
December 30, 2026
Transauricular Vagus Nerve Stimulation
Participants enrolled will have a commercial transcutaneous electrical nerve stimulation unit (tVNS501,RISHENA,Changzhou,China) attached to their left outer ear after VATS. The stimulation pulses will target at the cymba concha which is 100% dominated by the auricular branch of the vagus nerve. Stimulation pulses will be 25Hz in frequency according to current clinical research, 500µs in pulse width which has been suggested to be most biologically active, with its amplitude increasing to the maximum amount that the patients can tolerate without pain.
Sham Transauricular Vagus Nerve stimulation
The only thing differs with the taVNS group is that the device will automatically shut down after running for 15 seconds.
Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing
Peking Union Medical College Hospital
OTHER