NCT06911983View on ClinicalTrials.gov

Comparative Efficacy of Metformin and Berberine Among TCF7L2 (rs7903146) TT vs. CC Genotype Carriers With Type 2 Diabetes

NANot yet recruitingINTERVENTIONAL
Enrollment

60

Participants

Timeline

Start Date

July 1, 2025

Primary Completion Date

December 1, 2025

Study Completion Date

March 1, 2026

Conditions
Diabetes Mellitis
Interventions
DRUG

Metformin

Metformin • Initial dose: 500 mg twice daily • Titration: increased to 1,000 mg twice daily by Week 2 if tolerated • Maximal dose: 2,000 mg/day

DIETARY_SUPPLEMENT

Berberine

"Berberine~* Dose: 500 mg three times daily (1,500 mg/day total)~* Formulation: standardized berberine HCl tablets~* Duration: 12 weeks"

Trial Locations (1)

Unknown

Center for New Medical Technologies, Novosibirsk

All Listed Sponsors
collaborator

Center for New Medical Technologies, Novosibirsk, Russia

OTHER

lead

S.LAB (SOLOWAYS)

OTHER